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Effects of estradiol-17-beta on oxytocin and progesterone release of the bovine corpus luteum during the estrous cycle



Effects of estradiol-17-beta on oxytocin and progesterone release of the bovine corpus luteum during the estrous cycle



Journal of Reproduction & Development 41(3): 187-196



The effects of estradiol-17-beta (E-2) on progesterone (P-4) and oxytocin (OT) release were examined. Corpora lutea (CL) were obtained from cows at different stages of the estrous cycle (days lt 5, 5-7,8-12 and 15-18) and were implanted with an in vitro microdialysis system (MDS). A 3-h infusion with E-2 (100 nmol/l 1 nmol/l, 10 pmol/l and 100 fmol/l) shifted from no effect (days 5-7 and 8-12) to an inhibitory effect (days 15-18) on P-4 release during the estrous cycle. E2 at all test doses was most stimulative on the release of CT during the early luteal phase (days 5-7) but continuously inhibited CT release from the middle to late phase of the estrous cycle. Contrary to results obtained from days 5-7, in CL on days lt 5, a stimulation (100 nmol/l) or inhibition (1 nmol/l and 10 pmol/l) of CT release was observed. In contrast, preexposure to a potent, specific estrogen antagonist (ICI 182, 780; 10 nmol/l, 3 h) during the early luteal phase (days 5-7) showed no effect on P-4 release and completely impeded the stimulatory effect of E-2 on the CT release. In addition, a 3-h preexposure perfusion of ICI 182, 780 prevented the inhibition of CT secretion by E-2 on days 812. The results suggest that E-2 acts directly and acutely on the secretory function of bovine CL in the MDS during the early luteal stage (days 5-7) of the estrous cycle and may act together with the released CT as a luteotropic factor.

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