Section 10
Chapter 9,901

Low levels of estradiol facilitate, whereas high levels of estradiol impair, working memory performance on the radial arm maze

Holmes, M.M.; Wide, J.K.; Galea, L.A.M.

Behavioral Neuroscience 116(5): 928-934


ISSN/ISBN: 0735-7044
PMID: 12369813
DOI: 10.1037/0735-7044.116.5.928
Accession: 009900556

Download citation:  

Previous investigations of estradiol's effects on learning and memory yielded equivocal results. This study was designed to determine whether these inconsistencies were due to dose-dependent effects of estradiol on different memory processes. Ovariectomized female rats were injected daily with estradiol benzoate (EB; 0.32, 1.00, or 5.00 mg) or vehicle. Approximately 3 hr after injection, rats were run on a hippocampus-dependent working/reference memory version of the radial arm maze. Total number of working (WME), reference, and combined working/reference memory errors were scored. Compared with vehicle, 1.00 or 5.00 mg EB (high physiological) impaired performance by increasing the number of WME, whereas 0.32 mg EB (low physiological) facilitated performance by decreasing the number of WME. Taken together, these data demonstrate a dose-dependent effect of EB on working memory. Reprinted by permission of the publisher.

PDF emailed within 0-6 h: $19.90