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Mechanisms responsible for cypermethrin resistance in a strain of German cockroach, Blattella germanica



Mechanisms responsible for cypermethrin resistance in a strain of German cockroach, Blattella germanica



Pesticide Biochemistry and Physiology 66(3): 195-205



Cypermethrin resistance level and mechanisms responsible for the resistance were investigated in a strain (Aves) of German cockroach, Blattella germanica (L.), collected recently from a Gainesville, Florida residence. Topical bioassay data revealed that the Aves strain was highly resistant to cypermethrin, exhibiting a resistance ratio of 93-fold, which was reduced to 29-fold when cockroaches were pretreated with piperonyl butoxide and reduced to 18-fold when pretreated with S,S,S-tributyl phosphorotrithioate. The synergist data implicated enhanced oxidative and hydrolytic metabolism as resistance mechanisms in the Aves German cockroach strain. This conclusion was further supported by significantly higher oxidative (2.4- to 4.2-fold) and hydrolytic (1.6- to 3.6-fold) detoxification enzyme activities toward surrogate substrates and significantly higher in vitro [14C]cypermethrin metabolism. Microsomal NADPH-dependent (1.8-fold) and NADPH-independent (2.2-fold) [14C]cypermethrin metabolism were significantly greater in the Aves strain than in the Orlando insecticide-susceptible strain. In vivo penetration studies with [14C]cypermethrin indicated that decreased cypermethrin penetration may also be a contributing resistance mechanism in the Aves strain. Finally, the Leu993Phe mutation, shown previously to be associated with knockdown resistance (kdr), was present in the Aves strain. Copyright 2000 Academic Press.

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Accession: 009906309

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DOI: 10.1006/pest.1999.2462


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