Mutagenicity of cytostatic drugs in a bacterial system. II. DNA-repair test

Marhan, J.

Folia Microbiologica 40(5): 462-466

1995


ISSN/ISBN: 0015-5632
PMID: 8763145
Accession: 009917258

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Abstract
A liquid micromethod modification of the DNA-repair test using an automatic growth analyzer was developed. The wild strain Escherichia coli WP2 and six repair-deficient isogenic test strains were used. To compare this repair test with the conventional plate Ames test, a set of nine cytostatics were tested. Cloturin, adriamycin, mitoxantrone, oracin, lomustine and tris(2-chloroethyl)amine were found to be positive, and 6-mercaptopurine, butocin and cyclophosphamide negative. The experimental micromethod appears to be useful for assessing the differential lethality in bacteria and can be combined in any short-term test system to predict genotoxicity.