EurekaMag.com logo
+ Translate

NTBC and alkaptonuria


, : NTBC and alkaptonuria. American Journal of Human Genetics 63(3): 920-921

An alternative therapy for alkaptonuria that avoids the problem of gene localization is described. The signs and symptoms of alkaptonuria are thought to be caused by homogentisic acid (HA). The treatment involves the oral administration of the triketone herbicide 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC) combined with some dietary restriction of phenylalanine and tyrosine. As triketone herbicides inhibit 4-hydroxyphenylpyruvate dioxygenase, which is the enzyme that produces HA, therapy with NTBC should prevent HA production.

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 009919776

PMID: 9718357

DOI: 10.1086/302027

Download PDF Full Text: NTBC and alkaptonuria


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Khomutovskii O.A.; Perederei O.F.; Lutsik M.D.; Pogorelaya N.Kh; Yurchenko O.V., 1987: Estimation of lectin receptors distribution on the surface of tumors and transformed cells by variance statistics. Statistical procedures were used to estimate lectin receptor distribution on the surface of ascite lymphoma cells, neuroblastoma C-1300 cells and of transformed human T- and B-derived lymphoid cell lines. Relationships between the arithmetic means...

Hann L.E.; Sullivan D.A., 1987: Isolation characterization and hormonal response of lacrimal gland acinar cells. Investigative Ophthalmology & Visual Science 28(3 SUPPL): 157

Pickup, J., 1995: Where sensors lead. Lancet 346(8990): 1572-1573

Vasilevskaia, N.E.; Stankevich, L.N., 1977: Reactions of fish tectum mesencephali neurons to stimulation of skin chemoreceptors. Doklady Akademii Nauk SSSR 233(2): 502-505

Bailey, S.R.; Polan, J.L.; Feldman, M.D.; Agrawal, C.M., 2000: Endothelial seeding of gas-plasma treated polymer. American Journal of Cardiology 86(Suppl 8A): 86i, October 16

Anderson Jr; Audet; S.J.hn R, 2000: Practices in the Prevention of Venous Thromboembolism. Objective: The objective of this study was to determine the proportion of Massachusetts Medicare patients who received prophylaxis for venous thromboembolism following colectomy, hysterectomy, or total hip arthroplasty. Sample frame: All 90 Massac...

Gavrikov, S. A., 2001: The hydrological basis for rational use of water resources for rice irrigation. Hydrological assessment methods developed for the Amu Darya basin allow for use of the river water for rice irrigation and other crops. The method enables consideration to be given to water requirements both with and without upstream (using storag...

Seo, B.S.; Peterson, P.A., 2000: Transposition of the En/Spm transposable element system in maize Reciprocal crosses of a1-m and a1-m alleles uncover developmental patterns. Transposition studies of the transposon, En/Spm, have dealt with general aspects of the timing of the excision event with regard to DNA replication and plant development, but without describing details of the process. By following the excision eve...

Tsujimoto, Y., 1994: We admire nurses: students' symposium on team medicine. Japanese Journal of Nursing 46(12): 114-123

Gurewich, V., 1989: Importance of fibrin specificity in therapeutic thrombolysis and the rationale of using sequential and synergistic combinations of tissue plasminogen activator and pro-urokinase. Seminars in Thrombosis and Hemostasis 15(2): 123-128