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Oxygen and reduced umbilical blood flow trigger the first breath of human neonates



Oxygen and reduced umbilical blood flow trigger the first breath of human neonates



Acta Paediatrica Japonica 34(6): 660-662



The mechanism triggering the first breath of human neonates is still unclear. In order to investigate the role of oxygen and umbilical blood flow in the onset of the first breath, a total of 20 rat and rabbit fetuses were studied. All five rat fetuses delivered in a nitrogen chamber did not commence breathing of their own accord, whereas all five rabbit fetuses delivered in oxygenated fluorocarbon fluid commenced their own breathing, suggesting that contact with oxygen rather than release from submergence is more crucial in the initiation of the first breath.

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Accession: 009932285

Download citation: RISBibTeXText

PMID: 1285515

DOI: 10.1111/j.1442-200x.1992.tb01027.x


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