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Resistance of livestock to viruses: Mechanisms and strategies for genetic engineering

Resistance of livestock to viruses: Mechanisms and strategies for genetic engineering

Genetics Selection Evolution (Paris) 28(5): 385-414

This communication aims to inform readers from research and industry about the possibilities of developing genetic engineering strategies for improvement of resistance to viruses in livestock. It briefly reviews coevolution of hosts and parasites, principal elements of virus-host interactions, existing resistance mechanisms, and conventional methods for improvement of disease resistance. Research results from genetic engineering of new resistance mechanisms in both plants and animals, as well as investigation of possible risks and 'biological cost' of such mechanisms are summarized as a background for the discussion of prerequisites and strategies for future genetic engineering of resistance to viruses in livestock. It is concluded that, while conventional breeding methods will remain the principal approach to the improvement of disease resistance, in some instances the introduction of new, genetically engineered resistance mechanisms may be justified.

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Accession: 009963004

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DOI: 10.1186/1297-9686-28-5-385

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