EurekaMag
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Sample Size Determination for Establishing Equivalence/Noninferiority via Ratio of Two Proportions in Matched-Pair Design


Sample Size Determination for Establishing Equivalence/Noninferiority via Ratio of Two Proportions in Matched-Pair Design



Biometrics 58(4): 957-963



ISSN/ISBN: 0006-341X

PMID: 12495150

DOI: 10.2307/3068538

In this article, we propose approximate sample size formulas for establishing equivalence or noninferiority of two treatments in match-pairs design. Using the ratio of two proportions as the equivalence measure, we derive sample size formulas based on a score statistic for two types of analyses: hypothesis testing and confidence interval estimation. Depending on the purpose of a study, these formulas can be used to provide a sample size estimate that guarantees a prespecified power of a hypothesis test at a certain significance level or controls the width of a confidence interval with a certain confidence level. Our empirical results confirm that these score methods are reliable in terms of true size, coverage probability, and skewness. A liver scan detection study is used to illustrate the proposed methods.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 009969471

Download citation: RISBibTeXText

Related references

Sample Size Determination for Establishing Equivalence/Noninferiority via Ratio of two Proportions in Matched Pair Design. Biometrics 58(4): 957-963, 2002

Sample size determination for matched-pair equivalence trials using rate ratio. Biostatistics 8(3): 625-631, 2007

Matched-pair noninferiority trials using rate ratio: A comparison of current methods and sample size refinement. Controlled Clinical Trials 24(4): 364-377, 2003

Establishing equivalence of two treatments and sample size requirements in matched-pairs design. Biometrics 53(4): 1422-1430, 1997

Establishing equivalence of two treatments and sample size requirements in matched-pairs design. Biometrics 53(4): 1422-1430,., 1997

Formulas and tables for the determination of sample sizes and power in clinical trials for testing differences in proportions for the matched pair design: A review. Fundamental and Clinical Pharmacology 10(6): 554-563, 1996

Statistical analysis of noninferiority trials with a rate ratio in small-sample matched-pair designs. Biometrics 59(4): 1170-1177, 2003

Statistical Analysis of Noninferiority Trials with a Rate Ratio in Small-Sample Matched-Pair Designs. Biometrics 59(4): 70-7, 2003

Sample size determination for pair-matched case-control studies where the goal is interval estimation of the odds ratio. Journal of Clinical Epidemiology 43(1): 55-59, 1990

Tests for equivalence based on odds ratio for matched-pair design. Journal of Biopharmaceutical Statistics 15(6): 889-901, 2005

Statistical inference for noninferiority of difference in proportions of clustered matched-pair data from multiple raters. Journal of Biopharmaceutical Statistics 27(1): 70-83, 2017

Sample size determination for equivalence test using rate ratio of sensitivity and specificity in paired sample data. Controlled Clinical Trials 22(4): 373-389, 2001

Sample size determination and re-estimation for matched pair designs with multiple binary endpoints. Biometrical Journal. Biometrische Zeitschrift 55(3): 430-443, 2013

Sample size considerations for matched-pair cluster randomization design with incomplete observations of continuous outcomes. Contemporary Clinical Trials 104: 106336, 2021

Sample size considerations for matched-pair cluster randomization design with incomplete observations of binary outcomes. Statistics in Medicine 40(24): 5397-5416, 2021