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The possible alteration in the effect of glibenclamide by combined administration of calcium channel blockers on some carbohydrate metabolic aspects in rats



The possible alteration in the effect of glibenclamide by combined administration of calcium channel blockers on some carbohydrate metabolic aspects in rats



Egyptian Journal of Pharmaceutical Sciences 35(1-6): 643-652



The effect of two calcium channel blockers (CCBs) (verapamil (Ver) and nifedipine (Nif)) when given to combination with glibenclamide (Gb) on some carbohydrate metabolic aspects was studied in male albino rats. Short or long-term administration of CCBs along with Gb completely abolished the hypoglycaemic and hyperinsulinaemic effect of Gb. This was accompanied by a profound lowering of liver glycogen to 50% and 43% of the control values in combination of Ver and Nif with Gb respectively. Hepatic glucose 6-phosphatase (G-6-Pase) activity was not affected by short-term administration of CCBs with Gb as compared to the control values. However, on long-term administration of such combinations, the lowering effect of Gb on hepatic G-6 pase activity was abolished. Meanwhile, hepatic G-6-PDH activity was reduced in response to both short and long-term combined therapy of CCBs with Gb to an extent comparable to that caused by CCBs treatment alone. Possible explanations for such interactions are given.

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