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The receptor for interleukin 3 is selectively induced in human endothelial cells by tumor necrosis factor a and potentiates interleukin 8 secretion and neutrophil transmigration



The receptor for interleukin 3 is selectively induced in human endothelial cells by tumor necrosis factor a and potentiates interleukin 8 secretion and neutrophil transmigration



Proceedings of the National Academy of Sciences of the United States of America 90: 137-41



The in vivo role of interleukin 3 (IL-3) was investigated. A receptor for IL-3 was expressed by human umbilical vein endothelial cells (HUVECs) upon stimulation with tumor necrosis factor a (TNF-a), IL-1b, or lipopolysaccharide. The selective induction by TNF-a of IL-3 binding to HUVECs enhanced IL-8 formation, E-selectin expression, and neutrophil transmigration. These results indicate that, apart from its stimulation of hemopoiesis, IL-3 may be important in controlling inflammation in situations such as tumor immunity, chronic inflammation, and allergic diseases.

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Accession: 010010913

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