A critical role for cAMP response element-binding protein (CREB) as a Co-activator in sterol-regulated transcription of 3-hydroxy-3-methylglutaryl coenzyme A synthase promoter
Dooley, K.A.; Bennett, M.K.; Osborne, T.F.
Journal of Biological Chemistry 274(9): 5285-5291
1999
ISSN/ISBN: 0021-9258
PMID: 10026135
DOI: 10.1074/jbc.274.9.5285
Accession: 010058492
3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase, a key regulatory enzyme in the pathway for endogenous cholesterol synthesis, is a target for negative feedback regulation by cholesterol. When cellular sterol levels are low, the sterol regulatory element-binding proteins (SREBPs) are released from the endoplasmic reticulum membrane, allowing them to translocate to the nucleus and activate SREBP target genes.
PDF emailed within 0-6 h: $19.90
Related References
Ngo, T.T.; Bennett, M.K.; Bourgeois, A.L.; Toth, J.I.; Osborne, T.F. 2002: A role for cyclic AMP response element-binding protein (CREB) but not the highly similar ATF-2 protein in sterol regulation of the promoter for 3-hydroxy-3-methylglutaryl coenzyme a reductase Journal of Biological Chemistry 277(37): 33901-33905Inoue, J.; Sato, R.; Maeda, M. 1998: Multiple DNA elements for sterol regulatory element-binding protein and NF-Y are responsible for sterol-regulated transcription of the genes for human 3-hydroxy-3-methylglutaryl coenzyme a synthase and squalene synthase Journal of Biochemistry 123(6): 1191-1198
Mascaró, C.; Ortiz, J.A.; Ramos, M.M.; Haro, D.; Hegardt, F.G. 2000: Sterol regulatory element binding protein-mediated effect of fluvastatin on cytosolic 3-hydroxy-3-methylglutaryl-coenzyme a synthase transcription Archives of Biochemistry and Biophysics 374(2): 286-292
Dooley, K.A.; Millinder, S.; Osborne, T.F. 1998: Sterol regulation of 3-hydroxy-3-methylglutaryl-coenzyme A synthase gene through a direct interaction between sterol regulatory element binding protein and the trimeric CCAAT-binding factor/nuclear factor Y Journal of Biological Chemistry 273(3): 1349-1356
Osborne, T.F.; Gil, G.; Goldstein, J.L.; Brown, M.S. 1988: Operator constitutive mutation of 3-hydroxy-3-methylglutaryl coenzyme a reductase promoter abolishes protein binding to sterol regulatory element Journal of Biological Chemistry 263(7): 3380-3387
Ericsson, J.; Jackson, S.M.; Edwards, P.A. 1996: Synergistic binding of sterol regulatory element-binding protein and NF-Y to the farnesyl diphosphate synthase promoter is critical for sterol-regulated expression of the gene Journal of Biological Chemistry 271(40): 24359-24364
Vallett, S.M.; Sanchez, H.B.; Rosenfeld, J.M.; Osborne, T.F. 1996: A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene Journal of Biological Chemistry 271(21): 12247-12253
Morrison, L.S.; Pierotti, A.R. 2003: Thimet oligopeptidase expression is differentially regulated in neuroendocrine and spermatid cell lines by transcription factor binding to SRY (sex-determining region Y), CAAT and CREB (cAMP-response-element-binding protein) promoter consensus sequences Biochemical Journal 376(Pt 1): 189-197
Eggers, A.; Caudevilla, C.; Asins, G.; Hegardt, F.G.; Serra, D. 2000: Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase promoter contains a CREB binding site that regulates cAMP action in Caco-2 cells Biochemical Journal 345 Pt 2: 201-206
Than, T.A.; Lou, H.; Ji, C.; Win, S.; Kaplowitz, N. 2011: Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells Journal of Biological Chemistry 286(25): 22047-22054
Gonzales, M.; Bowden, G.Tim. 2002: Ultraviolet B (UVB) induction of the c-fos promoter is mediated by phospho-cAMP response element binding protein (CREB) binding to CRE and c-fos activator protein 1 site (FAP1) cis elements Gene 293(1-2): 169-179
Luskey, K.L. 1987: Conservation of the sterol regulated 3 hydroxy 3 methylglutaryl coenzyme a reductase promoter in man Clinical Research 35(3): 624A
Wilkin, D.J.; Edwards, P.A. 1992: Calcium ionophore treatment impairs the sterol-mediated suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-coenzyme A synthase, and farnesyl diphosphate synthetase Journal of Biological Chemistry 267(4): 2831-2836
Giono, L.E.; Varone, C.L.; Cánepa, E.T. 2001: 5-Aminolaevulinate synthase gene promoter contains two cAMP-response element (CRE)-like sites that confer positive and negative responsiveness to CRE-binding protein (CREB) Biochemical Journal 353(Pt 2): 307-316
Wu, X.; McMurray, C.T. 2001: Calmodulin kinase II attenuation of gene transcription by preventing cAMP response element-binding protein (CREB) dimerization and binding of the CREB-binding protein Journal of Biological Chemistry 276(3): 1735-1741
Kingsley Kallesen, M.L.; Kelly, D.; Rizzino, A. 1999: Transcriptional regulation of the transforming growth factor-b2 promoter by cAMP-responsive element-binding protein (CREB) and activating transcription factor-1 (ATF-1) is modulated by protein kinases and the coactivators p300 and CREB-binding protein Journal of Biological Chemistry 274(48): 020-028
Kingsley-Kallesen, M.L.; Kelly, D.; Rizzino, A. 1999: Transcriptional regulation of the transforming growth factor-beta2 promoter by cAMP-responsive element-binding protein (CREB) and activating transcription factor-1 (ATF-1) is modulated by protein kinases and the coactivators p300 and CREB-binding protein Journal of Biological Chemistry 274(48): 34020-34028
Choi, S.; Kim, W.; Chung, J. 2011: Drosophila salt-inducible kinase (SIK) regulates starvation resistance through cAMP-response element-binding protein (CREB)-regulated transcription coactivator (CRTC) Journal of Biological Chemistry 286(4): 2658-2664
Nogueira, E.F.; Rainey, W.E. 2010: Regulation of aldosterone synthase by activator transcription factor/cAMP response element-binding protein family members Endocrinology 151(3): 1060-1070
Tentler, J.J.; Hadcock, J.R.; Gutierrez-Hartmann, A. 1997: Somatostatin acts by inhibiting the cyclic 3',5'-adenosine monophosphate (cAMP)/protein kinase a pathway, cAMP response element-binding protein (CREB) phosphorylation, and CREB transcription potency Molecular Endocrinology 11(7): 859-866