Section 11
Chapter 10,059

A critical role for cAMP response element-binding protein (CREB) as a Co-activator in sterol-regulated transcription of 3-hydroxy-3-methylglutaryl coenzyme A synthase promoter

Dooley, K.A.; Bennett, M.K.; Osborne, T.F.

Journal of Biological Chemistry 274(9): 5285-5291


ISSN/ISBN: 0021-9258
PMID: 10026135
DOI: 10.1074/jbc.274.9.5285
Accession: 010058492

3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase, a key regulatory enzyme in the pathway for endogenous cholesterol synthesis, is a target for negative feedback regulation by cholesterol. When cellular sterol levels are low, the sterol regulatory element-binding proteins (SREBPs) are released from the endoplasmic reticulum membrane, allowing them to translocate to the nucleus and activate SREBP target genes.

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