Section 11
Chapter 10,059

A critical role of the N-methyl-D-aspartate (NMDA) receptor subunit (NR) 2A in the expression of redox sensitivity of NR1/NR2A recombinant NMDA receptors

Brimecombe, J.C.; Potthoff, W.K.; Aizenman, E.

Journal of Pharmacology and Experimental Therapeutics 291(2): 785-792


ISSN/ISBN: 0022-3565
PMID: 10525101
Accession: 010058532

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In recombinant N-methyl-D-aspartate (NMDA) receptors, two redox modulatory sites are thought to exist, one formed by Cys744 and Cys798 on NMDA receptor subunit (NR) 1, and a second one, not yet localized, on NR2A. Reductants increase the open dwell-time and opening frequency of NR1/NR2A channels. In contrast, NR1/NR2B and NR1/NR2C channels exhibit changes only in opening frequency after redox treatments.

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