A high affinity binding site for the polypyrimidine tract binding protein (PTB) is located in the 5'-untranslated region of the rat proteinase alpha1-inhibitor 3 variant I gene
Sickinger, S.; Schweizer, M.
Biological Chemistry 380(10): 1217-1223
ISSN/ISBN: 1431-6730 PMID: 10595585 DOI: 10.1515/bc.1999.154
As a first step towards understanding the mechanism underlying the differential gene expression of the two variants of the rat proteinase-inhibitor alpha1-Inhibitor 3 (alpha1-I3) corresponding genomic clones were isolated. The 100% similarity between the sequence of one genomic clone and that of the alpha1-I3 variant I cDNA strongly suggested that its 5'-sequence represented the upstream region of the corresponding gene.