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A novel action of alzheimer's amyloid beta-protein (Abeta): oligomeric Abeta promotes lipid release



A novel action of alzheimer's amyloid beta-protein (Abeta): oligomeric Abeta promotes lipid release



Journal of Neuroscience 21(18): 7226-7235



Interactions between amyloid beta-protein (Abeta) and lipids have been suggested to play important roles in the pathogenesis of Alzheimer's disease. However, the molecular mechanism underlying these interactions has not been fully understood. We examined the effect of Abeta on lipid metabolism in cultured neurons and astrocytes and found that oligomeric Abeta, but not monomeric or fibrillar Abeta, promoted lipid release from both types of cells in a dose- and time-dependent manner.

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Accession: 010080738

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PMID: 11549733


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