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A randomized study comparing Crinone 8%* and intramuscular progesterone supplementation in in vitro fertilization-embryo transfer cycles



A randomized study comparing Crinone 8%* and intramuscular progesterone supplementation in in vitro fertilization-embryo transfer cycles



Fertility & Sterility 76(6): 1144-1149, December



Objective: To compare the efficacy of Crinone 8% intravaginal progesterone gel vs. IM progesterone for luteal phase and early pregnancy support after IVF-ET. Design: Randomized, open-label study. Setting: Academic medical center. Patient(s): Two hundred and one women undergoing IVF-ET. Intervention(s): Women were randomized to supplementation with Crinone 8% (90 mg once daily) or IM progesterone (50 mg once daily) beginning the day after oocyte retrieval. Main Outcome Measure(s): Pregnancy, embryo implantation, and live birth rates. Result(s): The women randomized to luteal phase supplementation with IM progesterone had significantly higher clinical pregnancy (48.5% vs. 30.4%; odds ratio (OR), 2.16; 95% confidence interval (CI), 1.21, 3.87), embryo implantation (24.1% vs. 17.5%; OR, 1.89; 95% CI, 1.08, 3.30), and live birth rates (39.4% vs. 24.5%; OR, 2.00; 95% CI, 1.10, 3.70) than women randomized to Crinone 8%. Conclusion(s): In women undergoing IVF-ET, once-a-day progesterone supplementation with Crinone 8%, beginning the day after oocyte retrieval, resulted in significantly lower embryo implantation, clinical pregnancy, and live birth rates compared with women supplemented with IM progesterone.

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Accession: 010091366

Download citation: RISBibTeXText

PMID: 11730742

DOI: 10.1016/s0015-0282(01)02872-2



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