+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

AVP V1a-R expression in the rat hypothalamus around parturition: Relevance to antipyresis at term



AVP V1a-R expression in the rat hypothalamus around parturition: Relevance to antipyresis at term



Experimental Neurology 183(2): 338-345



An endogenous antipyresis has been observed around parturition in several species, including rats. It has been proposed that the neuropeptide vasopressin is responsible for this antipyresis via an action on the V(1a) receptor subtype, but this concept is controversial. We therefore addressed the question of the regulation of V(1a) receptor expression within the rat hypothalamus around parturition, to assess its possible involvement in the antipyresis phenomenon observed at term. We analyzed V(1a) receptor mRNA and protein levels in the hypothalamus/preoptic area of female rats at Days 15 and 22 (parturition) of gestation, and at Day 5 of lactation. We used quantitative RT-PCR to assess the mRNA levels and designed a semiquantitative Western blot assay to analyze changes in protein levels between the three stages studied. No significant changes either in V(1a) receptor mRNA or protein levels were observed between the three stages, suggesting that variations in the hypothalamic V(1a) receptor expression levels alone cannot account for the endogenous antipyresis observed at term.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 010109621

Download citation: RISBibTeXText

PMID: 14552875

DOI: 10.1016/s0014-4886(03)00114-6


Related references

Expression of c fos in crh neurons of the fetal hypothalamus during parturition in the sheep. Society for Neuroscience Abstracts 16(1): 453, 1990

Prostaglandin synthesis by the pregnant rat uterus at term and its possible relevance in parturition. British Journal of Pharmacology 47(3): 628p-629p, 1973

Changes in the expression of orexin and its receptors in the rat hypothalamus during pregnancy, parturition and lactation. Jiepou Xuebao 38(2): 134-138, 2007

Fos expression within regions of the preoptic area, hypothalamus and brainstem during pregnancy and parturition. Brain Research. 669(1): 115-124, 1995

Aspirin may exert its antipyresis by inhibiting the N-methyl-D-aspartate receptor-dependent hydroxyl radical pathways in the hypothalamus. Journal of Pharmacological Sciences 103(3): 293-298, 2007

Comparison of the expression of two immediate early gene proteins, FosB and Fos in the rat preoptic area, hypothalamus and brainstem during pregnancy, parturition and lactation. Neuroscience Research 32(4): 333-341, 1998

Comparison of the expression of two immediate early gene proteins, FosB and Fos in the rat preoptic area, hypothalamus and brainstem during pregnancy, parturition and lactation. Neuroscience Research 32(4): 333-341, 1999

Parturition in goats studies on the interactions between the fetus placenta prostaglandin f and progesterone before parturition at term or at parturition induced prematurely by corticotropin infusion of the fetus. Journal of Endocrinology 73(2): 263-278, 1977

Parturition in goats: studies on the interactions between the foetus, placenta, prostaglandin F and progesterone before parturition, at term or at parturition induced prematurely by corticotrophin infusion of the foetus. Journal of Endocrinology 73(2): 263-278, 1977

Variation in the expression of orexin and orexin receptors in the rat hypothalamus during the estrous cycle, pregnancy, parturition, and lactation. Endocrine 22(2): 127-134, 2003

Hamster airway at parturition: ultrastructure of the full-term fetal trachea and effects of parturition. Anatomical Record 229(1): 61-72, 1991

Expression of adhesion molecules in the lower uterine segment during term and preterm parturition. Microscopy Research and Technique 60(4): 430-444, 2003

Changes in myometrial expression of progesterone receptor membrane components 1 and 2 are associated with human parturition at term. Reproduction Fertility and Development 28(5): 618-627, 2016