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Absorption and excretion of chromium from orally administered chromium chloride, chromium acetate and chromium oxide in rats



Absorption and excretion of chromium from orally administered chromium chloride, chromium acetate and chromium oxide in rats



Trace Elements & Electrolytes 20(1): 23-28



There is a growing interest in the absorption of different forms of trivalent chromium. In the current study, we evaluated the absorption and excretion of chromium after single-dose administration of 3 chromium compounds (chromium chloride hexahydrate, chromium oxide and chromium acetate hydroxide), compared to a control, in male Sprague Dawley rats. These rats were dosed at 1000 mg/kg per compound. 24-hour urine collection and tissue samples were analyzed for chromium content. Animals were observed twice daily for mortality and clinical signs of toxicity. Gross observations were recorded at necropsy. Postmortem findings were observed only in rats administered chromium chloride. These findings included stomachs distended with fluid and gas, and ulceration of the mucosal lining of the stomachs. Trace levels of chromium were detected in urine samples from rats administered chromium oxide (group mean < 0.2 mg/1) while urinary chromium levels for the rats given chromium chloride and chromium acetate were 174 mg/l and 93 mg/l, respectively. Elevated levels of chromium were observed in liver, kidney, heart and pancreas samples collected from the rats administered chromium chloride and chromium acetate, compared to chromium levels detected in the chromium oxide and control groups. Evaluation of chromium levels in urine and tissues show that chromium oxide was poorly absorbed compared to chromium chloride hexahydrate and chromium acetate hydroxide. Additionally, while chromium chloride hexahydrate was readily absorbed, toxic effects were observed.

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Accession: 010113084

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