+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Addition of nitric oxide via nitroflurbiprofen enhances the material properties of early healing of young rat Achilles tendons

Addition of nitric oxide via nitroflurbiprofen enhances the material properties of early healing of young rat Achilles tendons

Inflammation Research 52(6): 230-237

To determine if the addition of nitric oxide (NO) via nitroflurbiprofen (NO-flurbiprofen) would enhance rat Achilles tendon healing. Sixty-five male Sprague-Dawley rats were randomly divided into NO-flurbiprofen, flurbiprofen and vehicle groups, given drugs or vehicle subcutaneously, and their right Achilles tendon divided. Histological assessment was carried out at day 5, 10, and 15 post-operation. Healing tendon biomechanical properties and hydroxyproline content were measured at day 10. The healing Achilles tendon from the NO-flurbiprofen and flurbiprofen groups showed a better organization of extracellular collagenous matrix than that from the vehicle group. Flurbiprofen and NO-flurbiprofen decreased healing tendon cross-sectional area by 30% and 20%. This reduction was accompanied by a decreased failure load in the flurbiprofen group, but not the NO-flurbiprofen group. NO-flubiprofen prevented the reduction of body weight gain observed in the flubiprofen group. Both flurbiprofen and NO-flurbiprofen promoted better collagen reorganization during tendon healing. NO-flurbiprofen further improved tendon healing by increasing tendon stress and reducing the side effects (body weight loss) of flurbiprofen. The enhanced tendon healing by NO-flurbiprofen is likely due to the release of NO from the compound.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 010128976

Download citation: RISBibTeXText

PMID: 12835894

DOI: 10.1007/s00011-003-1167-7

Related references

Addition of nitric oxide through nitric oxide-paracetamol enhances healing rat achilles tendon. Clinical Orthopaedics and Related Research 466(7): 1618-1624, 2008

Early controlled tension improves the material properties of healing human achilles tendons after ruptures: a randomized trial. American Journal of Sports Medicine 41(11): 2550-2557, 2013

Tenocytes from ruptured and tendinopathic achilles tendons produce greater quantities of type III collagen than tenocytes from normal achilles tendons. An in vitro model of human tendon healing. American Journal of Sports Medicine 28(4): 499-505, 2000

Differential effects of the nonsteroidal antiinflammatory drug flurbiprofen and its nitric oxide-releasing derivative, nitroflurbiprofen, on prostaglandin E(2), interleukin-1beta, and nitric oxide synthesis by activated microglia. Journal of Neuroscience Research 66(4): 715-722, 2001

Early E-modulus of healing Achilles tendons correlates with late function: similar results with or without surgery. Scandinavian Journal of Medicine and Science in Sports 22(1): 18-23, 2012

Temporal expression of nitric oxide synthase isoforms in healing Achilles tendon. Journal of Orthopaedic Research 19(1): 136-142, 2001

The cell specific temporal expression of nitric oxide synthase isoforms during Achilles tendon healing. Inflammation Research 50(10): 515-522, 2001

Nitroflurbiprofen, a nitric oxide-releasing cyclooxygenase inhibitor, improves cirrhotic portal hypertension in rats. Gastroenterology 132(2): 709-719, 2007

Early tensile properties of healing chicken flexor tendons: early controlled passive motion versus postoperative immobilization. Journal of Hand Surgery 15A(1): 63-68, 1990

Physical training and connective tissues in young mice--physical properties of Achilles tendons and long bones. Growth 41(2): 123-137, 1977

Nitric oxide enhances experimental wound healing in diabetes. British Journal of Surgery 89(12): 1594-1601, 2002

Effect of a new non-steroidal anti-inflammatory drug, nitroflurbiprofen, on the expression of inducible nitric oxide synthase in rat neutrophils. British Journal Of Pharmacology. 115(2): 225-226, 1995

Effects of boric acid on the healing of Achilles tendons of rats. Knee Surgery Sports Traumatology Arthroscopy 24(12): 3738-3744, 2016

Functional weight-bearing mobilization after Achilles tendon rupture enhances early healing response: a single-blinded randomized controlled trial. Knee Surgery Sports Traumatology Arthroscopy 25(6): 1807-1816, 2017