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Chapter 10,141

Agonist-induced phosphorylation of somatostatin receptor subtype 1 (sst1) . Relationship to desensitization and internalization

Liu, Q.; Schonbrunn, A.

Journal of Biological Chemistry 276(5): 3709-3717

2000

ISSN/ISBN: 0021-9258
PMID: 11073961
DOI: 10.1074/jbc.m008873200
Accession: 010140037
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The sst1 somatostatin (SRIF) receptor subtype is widely expressed in the endocrine, gastrointestinal, and neuronal systems as well as in hormone-sensitive tumors, yet little is known about its regulation. Here we investigated the desensitization, internalization, and phosphorylation of sst1 expressed in CHO-K1 cells. Treatment of cells with 100 nM SRIF for 30 min reduced maximal SRIF inhibition of adenylyl cyclase from 40 to 10%.

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