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An evaluation of the change in electrocardiographic P-wave variables after acute caffeine ingestion in normal volunteers



An evaluation of the change in electrocardiographic P-wave variables after acute caffeine ingestion in normal volunteers



Journal of Clinical Pharmacy & Therapeutics 26(2): 145-148



Background: Caffeine's effect on supraventricular dysrhythmias is poorly understood, and establishing a marker to predict atrial fibrillation may help to explain supraventricular dysrhythmias caused by caffeine. Objective: To evaluate the effects of caffeine (mean 6.1 mg/kg) on maximum P-wave duration and P-wave dispersion in normal volunteers. Method: A randomised, double-blind, placebo-controlled, crossover study in 10 healthy volunteers at least 17 years of age at the University of Connecticut. Participants abstained from caffeinated products for at least 2 days before study initiation and were randomly allocated on different days to receive placebo or caffeine 400 mg. For each of the study phases, a baseline 12-lead electrocardiogram (ECG) was performed and a subsequent 12-lead ECG was performed 3 h after ingesting the study drug. Results: No significant changes were found within intra- or intergroup comparisons for any P-wave variables measured. Conclusions: Single dose caffeine (400 mg) does not affect average P-wave duration, maximum P-wave duration or P-wave dispersion in normal individuals.

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Accession: 010159873

Download citation: RISBibTeXText

PMID: 11350538

DOI: 10.1046/j.1365-2710.2001.00336.x


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