+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

An outbreak of neonatal deaths in Brazil associated with contaminated intravenous fluids

An outbreak of neonatal deaths in Brazil associated with contaminated intravenous fluids

Journal of Infectious Diseases 186(1): 81-86

A nursery outbreak of fever and clinical sepsis resulted in the deaths of 36 neonates in Roraima, Brazil. To determine the cause, epidemiologic studies were performed, along with culture and endotoxin analysis of intravenous (iv) fluids. Affected neonates were more likely to have lower birth weight (2.1 vs. 3.2 kg; P<.01), lower APGAR (activity, pulse, grimace, appearance, and respiration) score at 1 (7 vs. 8; P=.1) or 5 min (8 vs. 9; P=.03), lower gestational age (32 vs. 39 weeks; P=.001), or to receive iv medications (20/20 vs. 2/40; P<.0001). Fever occurred only after iv medication administration. Although culture results of unopened iv medications were negative, endotoxin levels of glucose and distilled water for injection were elevated (3.3 and 1.2 U/mL, respectively). Endotoxin-contaminated iv medications were distributed nationally and may have caused other outbreaks of unexplained death. These results highlight the importance of monitoring both pharmaceutical quality and postmarketing surveillance for adverse events.

(PDF same-day service: $19.90)

Accession: 010164321

Download citation: RISBibTeXText

PMID: 12089665

DOI: 10.1086/341083

Related references

Sepsis caused by contaminated intravenous fluids. Epidemiologic, clinical, and laboratory investigation of an outbreak in one hospital. Annals of Internal Medicine 77(6): 881-890, 1972

Outbreak of Serratia marcescens postsurgical bloodstream infection due to contaminated intravenous pain control fluids. International Journal of Infectious Diseases 17(9): E718-E722, 2014

Comparison of short-term infusion regimens of N-acetylcysteine plus intravenous fluids, sodium bicarbonate plus intravenous fluids, and intravenous fluids alone for prevention of contrast-induced nephropathy in the emergency department. Academic Emergency Medicine 21(6): 615-622, 2014

Outbreak of hospital infection caused by contaminated autoclaved fluids. Lancet 1(7763): 1258-1260, 1972

An outbreak of neonatal deaths in foals due to Actinobacillus equuli. Veterinary Record 90(22): 630-632, 1972

An outbreak of neonatal deaths among term infants associated with administration of chloramphenicol. Journal of Pediatrics 59: 21-34, 1961

Investigation of contaminated parenteral nutrition fluids associated with an outbreak of Serratia odorifera septicaemia. Journal Of Hospital Infection. 27(4): 263-273, 1994

Septicemia due to contaminated intravenous fluids: a point to remember. Military Medicine 160(10): A12-A13, 1995

Inadvertent administration of intravenous fluids contaminated with fungus. Annals of Internal Medicine 91(4): 563-565, 1979

Estimated deaths and illnesses averted during fungal meningitis outbreak associated with contaminated steroid injections, United States, 2012-2013. Emerging Infectious Diseases 21(6): 933-940, 2015

Investigations on a spontaneous outbreak of aflatoxin-induced abortions and neonatal deaths in goats. Journal of Veterinary and Animal Sciences 21(2): 84-86, 1990

Enterobacter sepsis in infants and children due to contaminated intravenous fluids. Infection Control (Thorofare) 5(10): 471-477, 1984

Air pollution and neonatal deaths in Sao Paulo, Brazil. Brazilian Journal of Medical & Biological Research 37(5): 765-770, 2004