+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Angiotensin-converting enzyme gene polymorphism in untreated essential hypertension and response to angiotensin converting enzyme inhibitors



Angiotensin-converting enzyme gene polymorphism in untreated essential hypertension and response to angiotensin converting enzyme inhibitors



Yaoxue Xuebao 34(9): 655-657



AIM: To study the insertion/deletion(I/D) polymorphism of angiotensin-converting enzyme (ACE) gene in untreated essential hypertension, and the effect of angiotensin converting enzyme inhibitor (ACEI) on the gene polymorphism. METHODS: I/D Polymorphism in intron 16 of the ACE gene were determined by polymerase chain reaction (PCR) in 99 normotensive subjects and 40 patients with untreated essential hypertension before and after captopril treatment (50 mg twice daily). The change of diastolic blood pressure achieved was analyzed for association with genotypes at the ACE gene. RESULTS: No significant difference was found on the alleles frequencies and on the genotype frequencies between normotensive and hypertensive groups, effective and no effective response to ACEI groups(P > 0.05). Statistical analysis of DD genotype and non DD genotype, non II genotype and II genotype showed no significant difference between normotensive and hypertensive groups, effective and noneffective response to ACEI groups (P > 0.05). CONCLUSION: Deletion polymorphism of the ACE gene is not associated with essential hypertension. The variability between individuals in the observed blood pressure response to ACEI cannot be attributed to the polymorphisms analyzed at the ACE gene.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 010177589

Download citation: RISBibTeXText


Related references

Effect of the insertion/deletion polymorphism of the angiotensin-converting enzyme gene on response to angiotensin-converting enzyme inhibitors in patients with heart failure. Journal of Cardiovascular Pharmacology 32(6): 988-994, 1998

Murine Recombinant Angiotensin-Converting Enzyme 2 Effect on Angiotensin II-Dependent Hypertension and Distinctive Angiotensin-Converting Enzyme 2 Inhibitor Characteristics on Rodent and Human Angiotensin-Converting Enzyme 2 Renin-Angiotensin-Aldosteron. 2012

Does the angiotensin converting enzyme gene polymorphism affect patient response to angiotensin II antagonism in essential hypertension. Circulation 96(8 Suppl. ): I719, 10/21/97, 1997

Murine recombinant angiotensin-converting enzyme 2: effect on angiotensin II-dependent hypertension and distinctive angiotensin-converting enzyme 2 inhibitor characteristics on rodent and human angiotensin-converting enzyme 2. Hypertension 60(3): 730-740, 2013

Predictors of coronary in-stent restenosis: Importance of angiotensin-converting enzyme gene polymorphism and treatment with angiotensin-converting enzyme inhibitors. Journal of the American College of Cardiology 38(5): 1434-1439, 2001

Association of angiotensin I-converting enzyme gene polymorphism with susceptibility to antiproteinuric effect of angiotensin I-converting enzyme inhibitors in patients with proteinuria. Journal of the American Society of Nephrology 6(6): 1676-1678, 1995

I/D gene polymorphism of the angiotensin-converting enzyme and left ventricular hypertrophy. Response to converting enzyme inhibitors. Archives des Maladies du Coeur et des Vaisseaux 96(7-8): 772-775, 2003

Association of angiotensin-converting enzyme and angiotensin-converting enzyme-2 gene polymorphisms with essential hypertension in the population of Odisha, India. Annals of Human Biology 41(2): 145-152, 2014

Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial. Journal of Hypertension 25(10): 2082-2092, 2007

The relationship between polymorphism of angiotensin converting enzyme gene and cough caused by angiotensin converting enzyme inhibitors. Zhonghua Jie He He Hu Xi Za Zhi 26(4): 203-205, 2003

Relationship between polymorphism of angiotensin converting enzyme gene and cough caused by angiotensin converting enzyme inhibitors. Wuhan Daxue Xuebao (Yixue Ban) 29(1): 92-94,125, 2008

Usefulness of angiotensin converting enzyme inhibitors in the diagnosis of renovascular hypertension. II. Comparison of the effect of angiotensin converting enzyme inhibition on reno-scintigraphic curves with DTPA in patients with essential and renovascular hypertension. Przeglad Lekarski 54(7-8): 524-528, 1997

Relationship between polymorphism of the angiotensin-converting enzyme gene and the response to angiotensin-converting enzyme inhibition in hypertensive patients. Hypertension Research 26(11): 881-886, 2004

Relationship between Polymorphism of the Angiotensin-Converting Enzyme Gene and the Response to Angiotensin-Converting Enzyme Inhibition in Hypertensive Patients. Hypertension Research 26(11): 881-886, 2003

Angiotensin-converting enzyme inhibitor versus angiotensin 2 receptor antagonist therapy and the influence of angiotensin-converting enzyme gene polymorphism in IgA nephritis. Annals of the Academy of Medicine, Singapore 37(5): 372-376, 2008