+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Anti-metastatic and anti-angiogenic activities of a new matrix metalloproteinase inhibitor, TN-6b



Anti-metastatic and anti-angiogenic activities of a new matrix metalloproteinase inhibitor, TN-6b



European Journal of Cancer 39(11): 1632-1641



We investigated the anti-metastatic and anti-angiogenic effects of TN-6b, a new broad-spectrum inhibitor of matrix metalloproteinases (MMPs), against Lewis lung carcinoma (LLC) and hepatic sinusoidal endothelial (HSE) cells. TN-6b potently inhibited the activities of MMP-2 and -9 secreted by LLC and HSE cells in a zymogram assay. TN-6b, at non-cytotoxic concentrations, caused a marked inhibition of invasion and migration of LLC, and tube-like formation of HSE cells. In contrast, TN-6d, an inactive enantiomer of TN-6b, did not inhibit the invasion and tube-like formation. Daily subcutaneous (s.c.) administration of TN-6b at doses of 30 and 60 mg/kg in mice resulted in a potent inhibition of tumour-induced angiogenesis of B16 melanomas and lymph node metastasis of LLC cells. In conclusion, TN-6b effectively inhibited lymph node metastasis of LLC cells through its anti-invasive and anti-angiogenic properties. These findings suggest that the MMP inhibition correlates well with its anti-angiogenic and anti-metastatic efficacy and TN-6b has the therapeutic potential to inhibit angiogenesis and metastasis in vivo and in vitro.

(PDF emailed within 0-6 h: $19.90)

Accession: 010182345

Download citation: RISBibTeXText

PMID: 12855272

DOI: 10.1016/s0959-8049(03)00375-7


Related references

Phyllanthus spp. Exerts Anti-Angiogenic and Anti-Metastatic Effects Through Inhibition on Matrix Metalloproteinase Enzymes. Nutrition and Cancer 67(5): 783-795, 2016

BAY 12-9566, a novel, biphenyl matrix metalloproteinase inhibitor, demonstrates anti-invasive and anti-angiogenic properties. Proceedings of the American Association for Cancer Research Annual Meeting 39: 302, 1998

Anti-angiogenic and anti-tumor invasive activities of tissue inhibitor of metalloproteinase-3 from shark, Scyliorhinus torazame. Biochimica et Biophysica Acta 1620(1-3): 59-64, 17 March, 2003

Paeonol exerts anti-angiogenic and anti-metastatic activities through downmodulation of Akt activation and inactivation of matrix metalloproteinases. Biological and Pharmaceutical Bulletin 32(7): 1142-1147, 2009

Anti-tumor angiogenic effect of a matrix metalloproteinase inhibitor MMI270. Anticancer Research 23(1a): 411-417, 2003

The anti-angiogenic effect of halofuginone Inhibition of collagen type I tube formation, matrix metalloproteinase-2 activities and extracellular matrix deposition. Blood 96(11 Part 1): 34a, November 16, 2000

Catalytic activity of Matrix metalloproteinase-19 is essential for tumor suppressor and anti-angiogenic activities in nasopharyngeal carcinoma. International Journal of Cancer 129(8): 1826-1837, 2012

Anti-metastatic efficacy and safety of MMI-166, a selective matrix metalloproteinase inhibitor. Clinical and Experimental Metastasis 18(1): 61-66, 2001

Anti-metastatic efficacy and safety of MMI-166, a selective matrix metalloproteinase inhibitor. Clinical and Experimental Metastasis 18(1): 61-66, 2000

Diacetyloxyl derivatization of the fibroblast growth factor inhibitor dobesilate enhances its anti-inflammatory, anti-angiogenic and anti-tumoral activities. Journal of Translational Medicine 13: 48, 2016

Strategy for the clinical application of anti-angiogenic therapy against hepatocarcinogenesis and proliferation of hepatocellular carcinoma Mainly focused on matrix metalloproteinase inhibitor and HCV. Hepatology 32(4 Pt 2): 478A, 2000

Augmented anti-metastatic efficacy of a selective matrix metalloproteinase inhibitor, MMI-166, in combination with CPT-11. Clinical and Experimental Metastasis 19(6): 519-526, 2002

An appraisal of cinnamyl sulfonamide hydroxamate derivatives (HDAC inhibitors) for anti-cancer, anti-angiogenic and anti-metastatic activities in human cancer cells. Chemico-Biological Interactions 253: 112-124, 2017

Anti-metastatic and anti-angiogenic activities of sulfated polysaccharide of Sepiella maindroni ink. Carbohydrate Polymers 91(1): 403-409, 2013

Hypotoxic copper complexes with potent anti-metastatic and anti-angiogenic activities against cancer cells. Dalton Transactions 47(14): 5049-5054, 2018