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Anti-tumor immunity generated by tumor cells engineered to express B7-1 via retrovial or adenoviral gene transfer

Anti-tumor immunity generated by tumor cells engineered to express B7-1 via retrovial or adenoviral gene transfer

Cancer Letters 135(1): 1-10

We engineered B7-1 retroviral and adenoviral gene transfer systems and studied them in four immunogenic tumor models. M-MSV tumor cells, but not K-Balb, 38.2 and 205 tumor cells, when expressing B7-1 by retroviral transduction were rejected and conferred protection against a tumor challenge. Transient expression of B7-1 after transduction with adenoviruses was less efficient. We observed enhanced cytotoxic T-lymphocyte activity accompanied by increased secretion of IL-6, IFNgamma and GM-CSF. GM-CSF secretion correlated with tumor rejection. Enhanced IFNgamma but unchanged IL-4 secretion suggested a T-helper 1-mediated anti-tumor immune response.

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Accession: 010182706

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PMID: 10077215

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