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Antibacterial activity evaluation of microcin J25 against diarrheagenic Escherichia coli

Antibacterial activity evaluation of microcin J25 against diarrheagenic Escherichia coli

Applied and environmental microbiology 66(10): 4595-4597

The inhibitory activities of known microcins were evaluated against some diarrheagenic Escherichia coli strains. Some antibacterial properties of microcin J25, the most active one, were studied. A rapid two-step purification was performed. The MIC and the minimum bactericidal concentration of J25 against E. coli 0157:H7 were 1 and 100 microgram ml-1, respectively. A 10(4)-CFU ml-1 contamination by this strain was destroyed in milk and meat extract by 6.25 microgram of J25 ml-1 and in half-diluted egg yolk by 50 microgram of J25 ml-1.

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Accession: 010183111

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PMID: 11010926

DOI: 10.1128/aem.66.10.4595-4597.2000

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