Section 11
Chapter 10,194

Apoptosis mediated regression of transplantable LS lymphosarcoma in CBA mice treated with ACVP (adriamycin, cyclophosphamide, vincristine, prednisolone) or cyclophosphamide alone

Kaledin, V.I.; Nikolin, V.P.; Timofeeva, O.A.; Filipenko, M.L.; Baymak, T.Y.; Galyamova, M.R.; Popova, N.A.

Eksperimental'naya Onkologiya 24(1): 55-58


ISSN/ISBN: 0204-3564
Accession: 010193860

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The antitumor activity of a four-drug combination, cyclophosphamide (CP), adriamycin, vincristine, and prednisolone, was studied on a transplantable lymphosarcoma LS in CBA mice. A single injection of the drug mixture produced a complete regression of the tumor transplants in all animals. The effect was found to be elicited by CP, not by any other constituent of the mixture. Morphological analyses of tumor slices and DNA electrophoresis evidenced that tumors regressed by apoptosis.

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