Association of estrogen receptor gene polymorphisms with coronary heart disease
Huang-Xianzhang; Zhang-Pingan; Li-Yan; Et-Al
Zhonghua Xinxueguanbing Zazhi 30(2): 78-81
ISSN/ISBN: 0253-3758 Accession: 010212384
Objective To study the distribution of estrogen receptor(ER) polymorphisms in Chinese Han population and the association of the polymorphisms with coronary heart disease (CHD). Methods ER genotyping was performed in 135 CHD patients and 118 controls by using PCR-RFLP method. The serum lipid levels were also determined. Selected coronary angiography (SCA) were performed in 46 CHD patients. Results ER allelic frequencies of X, x and P, p alleles were 0.170, 0.830; 0.169, 0.831 and 0.256, 0.744, 0.399, 0.661 in CHD group and control group respectively. There was no significant difference in frequencies of allele and genotype in XbaI polymorphism or XbaI with PvuII polymorphisms together between CHD group and control group (P > 0.05). The serum lipid levels and the results of SCA were also not significantly different among genotypes within group. However, the distribution of PvuII genotypes was significantly different between the two groups or between myocardial infarction subgroup and angina pectoris subgroup (P < 0.05), respectively. Conclusion XbaI polymorphism is not related to CHD, but PvuII polymorphism is associated with CHD and might be a risk factor for CHD.