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Association study of dopamine D2, D3 receptor gene polymorphisms with motor fluctuations in PD



Association study of dopamine D2, D3 receptor gene polymorphisms with motor fluctuations in PD



Neurology 56(12): 1757-1759



The authors investigated the association between dopamine receptor D2, D3 gene polymorphisms, and the risk of developing motor fluctuations in PD. DRD3 BalI and MspI polymorphisms were not associated with risk of developing motor fluctuations. However, the genotypic distribution of DRD2 TaqIA polymorphism was significantly different in motor fluctuators and nonmotor fluctuators. These findings suggest that DRD2 TaqIA polymorphism may be associated with an increased risk for developing motor fluctuations in PD.

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Accession: 010213598

Download citation: RISBibTeXText

PMID: 11425949

DOI: 10.1212/wnl.56.12.1757


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