Auto-activation of the transforming viral interferon regulatory factor encoded by Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8)
Wang, X-Ping.; Gao, S-Jiang.
Journal of General Virology 84(Pt 2): 329-336
2003
ISSN/ISBN: 0022-1317 PMID: 12560564 DOI: 10.1099/vir.0.18653-0
Accession: 010219855
Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus-8-encoded viral interferon regulatory factor (vIRF) transforms NIH3T3 cells, represses interferon signal transduction and regulates the expression of other KSHV genes. Here, we have shown that vIRF is a transcriptional activator and auto-activates its own expression.
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