Section 11
Chapter 10,235

Benzydamine: An alternative nonsteroidal anti-inflammatory drug in patients with nimesulide-induced urticaria

Nettis, E.; Di Paola, R.; Napoli, G.; Ferrannini, A.; Tursi, A.

Allergy 57(5): 442-445


ISSN/ISBN: 0105-4538
PMID: 11972485
DOI: 10.1034/j.1398-9995.2002.13325.x
Accession: 010234357

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Background: Cutaneous adverse reactions to nonsteroidal anti-inflammatory drugs (NSAIDs), in particular urticaria/angiedema syndrome, represent a frequent problem in clinical practice. To date laboratory tests for the diagnosis of these adverse reactions are not available. A patient with an adverse drug reaction to NSAIDs needs an alternative drug to assume if necessary. Nimesulide is a highly prescribed nonsteroidal anti-inflammatory drug (NSAID) world-wide. It is also described as one of the most tolerated NSAID. In this paper we present data on the tolerability of benzydamine in nimesulide-sensitive patients. Patients and methods: One hundred and thirty-seven patients with nimesulide-induced urticaria were submitted to a single-blind, placebo-controlled peroral challenge with increasing doses of benzydamine. Results: One hundred and thirty-four out of 137 (98%) patients tolerated benzydamine without adverse effects, only three (2%) experienced immediate systemic urticaria (1 at the first dose and 2 at the second dose). Conclusion: Benzydamine is a well tolerated drug in patients with nimesulide-induced urticaria and it may represent a valid alternative NSAID in nimesulide-sensitive patients.

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