EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Brain opioid receptor measurements by positron emission tomography in normal cycling women: relationship to luteinizing hormone pulsatility and gonadal steroid hormones


Journal of Clinical Endocrinology and Metabolism 83(12): 4498-4505
Brain opioid receptor measurements by positron emission tomography in normal cycling women: relationship to luteinizing hormone pulsatility and gonadal steroid hormones
The regulation of central mu-opioid receptors in women during the menstrual cycle was explored with positron emission tomography and the selective radiotracer (11C)carfentanil. Ten healthy women were studied twice, during their follicular and luteal phases. Plasma concentrations of estradiol, progesterone, testosterone, and beta-endorphin were determined immediately before scanning. LH pulsatility was measured over the 9 h preceding each of the two positron emission tomography scans. No significant differences in the binding potential of mu-opioid receptors (binding capacity/Kd) were observed between phases of the menstrual cycle. However, significant negative correlations were observed between circulating levels of estradiol during the follicular phase and mu-receptor binding measures in the amygdala and hypothalamus, two regions thought to be involved in the regulation of GnRH pulsatility. LH pulse amplitude was positively correlated with mu binding in the amygdala, whereas LH pulse number was negatively correlated with binding in this same region. No significant associations were noted between LH pulse measures and the hypothalamus for this sample. These results suggest that amygdalar mu-opioid receptors exert a modulatory effect on GnRH pulsatility, and that circulating levels of estradiol also regulate central mu-opioid function.

(PDF same-day service: $19.90)

Accession: 010256093

PMID: 9851799

DOI: 10.1210/jcem.83.12.5351



Related references

Leptin levels and luteinizing hormone pulsatility in normal cycling women and their relationship to daily changes in metabolic rate. Fertility and Sterility 90(4): 1161-1168, 2008

Comparison of in vitro bioactivity and immunoactivity of serum luteinizing hormone released in normal cycling and hypo gonadal women throughout low dose luteinizing hormone releasing hormone studies. Biology of Reproduction 22(SUPPL 1): 51A, 1980

Genetic variant of luteinizing hormone: impact on gonadal steroid sex hormones in women. Physiological Research 50(6): 583-587, 2002

Effect of prolonged opioid receptor blockade on luteinizing hormone pulsatility luteinizing hormone responsiveness to gonadotropin releasing hormone and on serum estradiol levels. Acta Endocrinologica Supplementum 108(267): 5-6, 1985

Brain opioid receptor binding in early abstinence from opioid dependence: positron emission tomography study. British Journal of Psychiatry 191: 63-69, 2007

Positron emission tomography radiopharmaceuticals for sex steroid hormone receptor imaging. Current Medicinal Chemistry 19(20): 3266-3270, 2012

Role of endogenous opioid peptides in the initiation of the midcycle luteinizing hormone surge in normal cycling women. Journal of Clinical Endocrinology and Metabolism 67(4): 695-700, 1988

Thyroid hormones mediate steroid-independent seasonal changes in luteinizing hormone pulsatility in the ewe. Biology of Reproduction 66(3): 701-706, 2002

2-fluoro-2-deoxy-D-glucose positron emission tomography demonstration of estrogen negative and positive feedback on luteinizing hormone secretion in women. Journal of Clinical Endocrinology and Metabolism 93(8): 3208-3214, 2008

18F]2-fluoro-2-deoxy-D-glucose positron emission tomography demonstration of estrogen negative and positive feedback on luteinizing hormone secretion in women. Journal of Clinical Endocrinology and Metabolism 93(8): 3208-3214, 2008