+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Breast cancer incidence highest in the range of one species of house mouse, Mus domesticus



Breast cancer incidence highest in the range of one species of house mouse, Mus domesticus



British Journal of Cancer 82(2): 446-451



Incidence of human breast cancer (HBC) varies geographically, but to date no environmental factor has explained this variation. Previously, we reported a 44% reduction in the incidence of breast cancer in women fully immunosuppressed following organ transplantation (Stewart et al (1995) Lancet 346: 796-798). In mice infected with the mouse mammary tumour virus (MMTV), immunosuppression also reduces the incidence of mammary tumours. DNA with 95% identity to MMTV is detected in 40% of human breast tumours (Wang et al (1995) Cancer Res 55: 5173-5179). These findings led us to ask whether the incidence of HBC could be correlated with the natural ranges of different species of wild mice. We found that the highest incidence of HBC worldwide occurs in lands where Mus domesticus is the resident native or introduced species of house mouse. Given the similar responses of humans and mice to immunosuppression, the near identity between human and mouse MTV DNA sequences, and the close association between HBC incidence and mouse ranges, we propose that humans acquire MMTV from mice. This zoonotic theory for a mouse-viral cause of HBC allows testable predictions and has potential importance in prevention.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 010257194

Download citation: RISBibTeXText

PMID: 10646903

DOI: 10.1054/bjoc.1999.0941


Related references

Kidney structure in two species of arid zone rodent: Lakeland Downs short-tailed mouse, Leggadina lakedownensis, and the house mouse, Mus domesticus. Australian Mammalogy. June; 212: 251-255, 2000

Murine cytomegalovirus is not restricted to the house mouse Mus musculus domesticus: prevalence and genetic diversity in the European house mouse hybrid zone. Journal of Virology 89(1): 406-414, 2015

House sparrow Passer domesticus in Bietigheim-Bissingen with remarks on the phylogenetic species of house sparrows in the Palaearctic Ein Haussperling Passer domesticus in Bietigheim-Bissingen. Limicola, 122: 89-93, 1998

Characterization and comparison of major urinary proteins from the house mouse, Mus musculus domesticus, and the aboriginal mouse, Mus macedonicus. Journal of Chemical Ecology 33(3): 613-630, 2007

The distribution of the wood mouse Apodemus sylvaticus and the house mouse Mus domesticus on farmland in north-east Ireland. Irish Naturalists' Journal. January; 245: 199-203, 1993

Range expansion of the house sparrow passer domesticus through guatemala and el salvador. American Birds 40(2): 341-351, 1986

Causes and functions of intraspecific aggression the case of the house mouse Mus musculus domesticus Cause e funzioni dellaggressivita intraspecifica il caso del topolino delle case Mus musculus domesticus. Contributi del Centro Linceo Interdisciplinare 'Beniamino Segre': 97: 65-77, 1998

Egg recognition in the house sparrow Passer domesticus, a species where conspecific brood parasitism is very common Reconocimiento de huevos en el gorron comun Passer domesticus, una especie con parasitismo de cria intraespecifico. Ardeola. Diciembre; 482: 225-231, 2001

Population-genetic variability of the house mouse Mus musculus L. 1758 S. stricto from the western, central, and southeastern area of species range. Genetika 30(7): 906-912, 1994

Genetic variation in populations of the house mouse Mus musculus L. 1758 s. stricto from western, central, and southeastern parts of the species range. Genetika 30(7): 906-912, 1994

House mouse Mus domesticus Rutty, 1772.. Natuurhistorische Bibliotheek van de KNNV 56: 302-305, 1992

Predation and habitat shift in the house mouse mus domesticus. Ecology (Washington D C) 73(1): 313-322, 1992

Chemistry of male dominance in the house mouse, Mus domesticus. Experientia 46(1): 109-113, 1990

Constraints on home range behaviour affect nutritional condition in urban house sparrows Passer domesticus. Biological Journal of the Linnean Society: 41-50, 2010

Factors affecting home range size in house mice mus musculus domesticus living in outdoor enclosures. American Midland Naturalist 127(1): 31-40, 1992