+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Breathing He-O2 increases ventilation but does not decrease the work of breathing during exercise

Breathing He-O2 increases ventilation but does not decrease the work of breathing during exercise

American Journal of Respiratory and Critical Care Medicine 163(5): 1128-1134

We previously observed an increase in minute ventilation (V E) with resistive unloading (He-O2 breathing) in healthy elderly subjects with normal pulmonary function. To investigate the effects of resistive unloading in elderly subjects with mild chronic airflow limitation (FEV(1)/FVC: 61 +/- 4%), we studied 10 elderly men and women 70 +/- 3 yr of age. These subjects performed graded cycle ergometry to exhaustion, once breathing room air and once breathing a He-O2 gas mixture (79% He, 21% O2). V E, pulmonary mechanics, and PET(CO2) were measured during each 1-min increment in work rate. Data were analyzed by paired t test at rest, at ventilatory threshold (VTh), and during maximal exercise. V E was significantly (p < 0.05) increased at VTh (3.4 +/- 4.0 L/min or 12 +/- 15% increase) and maximal exercise (15.2 +/- 9.7 L/min or 22 +/- 13% increase) while breathing He-O2. Concomitant to the increase in V E, PET(CO2) was decreased at all levels (p < 0.01), whereas total work of breathing against the lung was not different. We concluded that V E is increased during He-O2 breathing because of resistive unloading of the airways and the maintenance of the relationship between the work of breathing and exercise work rate.

(PDF emailed within 0-6 h: $19.90)

Accession: 010257599

Download citation: RISBibTeXText

PMID: 11316648

DOI: 10.1164/ajrccm.163.5.9908025

Related references

Additional work of breathing and breathing patterns in spontaneously breathing patients during pressure support ventilation, automatic tube compensation and amplified spontaneous pattern breathing. European Journal of Anaesthesiology 22(4): 312-314, 2005

Irregular breathing during the cardiopulmonary exercise test - from mildly irregular breathing pattern to periodic breathing of oscillatory ventilation type. Vnitrni Lekarstvi 63(3): 175-182, 2017

Work of breathing during pressure support ventilation is not less than the work of breathing during assisted mechanical ventilation. American Review of Respiratory Disease 137(4 PART 2): 62, 1988

Evaluation of work of breathing in spontaneously breathing animals during partial liquid ventilation. Respiratory Care 47(1): 39-47, 2001

The effect of pressure support ventilation on breathing patterns and the work of breathing. Kokyu to Junkan. Respiration & Circulation 38(3): 269-272, 1990

A practical way to decrease imposed work of breathing to zero with pressure support ventilation. Anesthesiology 77(3A): A279, 1992

The effect of breath termination criterion on breathing patterns and the work of breathing during pressure support ventilation. Anesthesia and Analgesia 92(1): 161-165, 2001

Comparison of inspiratory work of breathing in T-piece breathing, PSV, and pleural pressure support ventilation (PPSV). Chest 100(4): 1030-1034, 1991

Use of the rapid/shallow breathing index as an indicator of patient work of breathing during pressure support ventilation. Surgery (St Louis) 122(4): 737-741, 1997

Imposed Work of Breathing During High-Frequency Oscillatory Ventilation in Spontaneously Breathing Neonatal and Pediatric Models. Respiratory Care 63(9): 1085-1093, 2018

Breathing frequency and pattern are poor predictors of work of breathing in patients receiving pressure support ventilation. Chest 108(5): 1338-1344, 1995

The effects of pressurization rate on breathing pattern, work of breathing, gas exchange and patient comfort in pressure support ventilation. European Respiratory Journal 18(1): 107-114, 2001

Work of breathing in anesthetized infants increases when a breathing system filter is used. Paediatric Anaesthesia 16(9): 939-943, 2006

Breathing exercise using a new breathing device increases airway secretion clearance in mechanically ventilated patients. Heart and Lung 42(3): 177-182, 2014

Inspiratory work of breathing is not decreased by flow-triggered sensing during spontaneous breathing in children receiving mechanical ventilation: a preliminary report. Pediatric Critical Care Medicine 5(4): 375-378, 2004