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Ca(2+) requirement for high-affinity gamma-aminobutyric acid (GABA) binding at GABA(B) receptors: involvement of serine 269 of the GABA(B)R1 subunit



Ca(2+) requirement for high-affinity gamma-aminobutyric acid (GABA) binding at GABA(B) receptors: involvement of serine 269 of the GABA(B)R1 subunit



Molecular Pharmacology 57(3): 419-426



The gamma-aminobutyric acid (GABA) receptor type B (GABABR) is constituted of at least two homologous proteins, GABABR1 and GABABR2. These proteins share sequence and structural similarity with metabotropic glutamate and Ca2+-sensing receptors, both of which are sensitive to Ca2+. Using rat brain membranes, we report here that the affinity of GABA and 3-aminopropylphosphinic acid for the GABABR receptor is decreased by a factor >10 in the absence of Ca2+.

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Accession: 010266175

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PMID: 10692480


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