+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Captopril treatment improves the sarcoplasmic reticular Ca(2+) transport in heart failure due to myocardial infarction



Captopril treatment improves the sarcoplasmic reticular Ca(2+) transport in heart failure due to myocardial infarction



Journal of Molecular and Cellular Cardiology 31(9): 1663-1672



Although captopril, an angiotensin-converting enzyme (ACE) inhibitor, has been shown to exert a beneficial effect on cardiac function in heart failure, its effect on the status of sarcoplasmic reticulum (SR) Ca(2+) transport in the failing heart has not been examined previously. In order to determine whether captopril has a protective action on cardiac function, as well as cardiac SR Ca(2+)-pump activity and gene expression, a rat model of heart failure due to myocardial infarction was employed in this study. Sham operated and infarcted rats were given captopril (2 g/l) in drinking water; this treatment was started at either 3 or 21 days and was carried out until 8 weeks after the surgery. The untreated animals with myocardial infarction showed increased heart weight and elevated left ventricular end diastolic pressure, reduced rates of pressure development and pressure fall, as well as depressed SR Ca(2+) uptake and Ca(2+)-stimulated ATPase activities in comparison with the sham control group. These hemodynamic and biochemical changes in the failing hearts were prevented by treatment of the infarcted animals with captopril. Likewise, the observed reductions in the SR Ca(2+) pump and phospholamban protein contents, as well as in the mRNA levels for SR Ca(2+) pump ATPase and phospholamban, in the failing heart were attenuated by captopril treatment. These results suggest that heart failure is associated with a defect in the SR Ca(2+) handling and a depression in the gene expression of SR proteins; the beneficial effect of captopril in heart failure may be due to its ability to prevent remodeling of the cardiac SR membrane.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 010274148

Download citation: RISBibTeXText

PMID: 10471350

DOI: 10.1006/jmcc.1999.1000


Related references

Depressed sarcoplasmic reticular calcium transport in congestive heart failure secondary to myocardial infarction. Journal of Molecular & Cellular Cardiology 21(SUPPL 2): S49, 1989

Sarcoplasmic reticular Ca2+ pump ATPase activity in congestive heart failure due to myocardial infarction. Canadian Journal of Cardiology 12(10): 1065-1073, 1996

Cardiac sarcoplasmic reticular function in rats with chronic heart failure following myocardial infarction. Journal of Molecular and Cellular Cardiology 29(2): 753-763, 1997

Effects of captopril in heart failure complicating acute myocardial infarction and persistence of acute haemodynamic effects in chronic heart failure after 3 years of treatment. Postgraduate Medical Journal 62 Suppl 1: 164-166, 1986

Baroreflex control of heart rate in rats with heart failure after myocardial infarction: effects of captopril. Journal of Pharmacology and Experimental Therapeutics 263(3): 1424-1431, 1992

Treatment with endothelin receptor antagonists improves renal dysfunction in rats with chronic heart failure following myocardial infarction. Journal of the American Society of Nephrology 9(PROGRAM AND ABSTR ISSUE): 574A, Sept, 1998

Effects of long-term therapy with ACE inhibitors, captopril, enalapril and trandolapril, on myocardial energy metabolism in rats with heart failure following myocardial infarction. Journal of Molecular and Cellular Cardiology 27(10): 2209-2222, 1995

Neuroendocrine effects of captopril in acute heart failure after myocardial infarction. European Heart Journal 9(ABSTR SUPPL 1): 3, 1988

Treatment with the endothelin-A receptor antagonist LU 135252 improves renal dysfunction in rats with chronic heart failure following myocardial infarction. European Heart Journal 20(ABSTR SUPPL ): 498, 1999

A novel drug delivery system of oral curcumin markedly improves efficacy of treatment for heart failure after myocardial infarction in rats. Biological & Pharmaceutical Bulletin 35(2): 139-144, 2012

Early treatment with hepatocyte growth factor improves cardiac function in experimental heart failure induced by myocardial infarction. Journal of Pharmacology and Experimental Therapeutics 304(2): 654-660, 2003

Hemodynamic effects of captopril in acute heart failure complicating myocardial infarction. American Heart Association Monograph: Ii-447, 1986

Effect of carvedilol and perindopril on Ca(2+) pump activity and Ca(2+)-release channel density in myocardial sarcoplasmic reticulum in rats with chronic heart failure following myocardial infarction. Nan Fang Yi Ke Da Xue Xue Bao 29(7): 1461-1464, 2013

Mortality and morbidity remain high despite captopril and/or Valsartan therapy in elderly patients with left ventricular systolic dysfunction, heart failure, or both after acute myocardial infarction: results from the Valsartan in Acute Myocardial Infarction Trial (VALIANT). Circulation 112(22): 3391-3399, 2005

A history of prior myocardial infarction was independently predictive of mortality but not of recurrent myocardial infarction or heart failure hospitalization in 5477 patients with acute myocardial infarction complicated by cardiac failure. Journal of the American College of Cardiology 39(5 Supplement A): 153A, March 6, 2002