+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Case-control and linkage disequilibrium studies of the tryptophan hydroxylase gene polymorphisms and major depressive disorder



Case-control and linkage disequilibrium studies of the tryptophan hydroxylase gene polymorphisms and major depressive disorder



Psychiatric Genetics 13(3): 151-154



Objectives: Alterations in the level of the serotonin, serotonin uptake and the number of binding sites have been linked to affective illness. We investigated the association of tryptophan hydroxylase gene polymorphisms and unipolar depression in a case-control study design. Methods: Patients and ethnically matched controls were genotyped for three polymorphisms of the tryptophan hydroxylase gene. Results: Significant difference in genotype frequency between patient and control groups was observed for the IVS7+218A>C polymorphism but not for the two promoter polymorphisms -1067G>A and -347T>G. Strong linkage disequilibrium among the three polymorphisms was also observed. Conclusions: As the sample size was small, the positive association would need to be replicated by family-based association studies or in a larger set of samples. As our results did not indicate association with either of the two promoter polymorphisms, there is a need to continue the search for the causative variant directly involved in the susceptibility to unipolar depression in Chinese as this polymorphism within the intron might not be the true susceptibility variant.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 010280453

Download citation: RISBibTeXText

PMID: 12960746


Related references

Case???control and linkage disequilibrium studies of the tryptophan hydroxylase gene polymorphisms and major depressive disorder. Psychiatric Genetics 13(3): 151-154, 2003

Characterisation of three polymorphisms of the tryptophan hydroxylase 2 gene in a sample of Colombian population with major depressive disorder. Revista Colombiana de Psiquiatria 46(1): 22-30, 2017

Effect of tryptophan hydroxylase gene polymorphism on aggression in major depressive disorder and undifferentiated somatoform disorder. Journal of Clinical Psychiatry 73(5): E574, 2012

The tryptophan hydroxylase gene influences risk for bipolar disorder but not major depressive disorder: results of meta-analyses. Bipolar Disorders 10(7): 816-821, 2008

Tryptophan hydroxylase 2 gene is associated with major depressive disorder in a female Chinese population. Journal of Affective Disorders 133(3): 619-624, 2011

Tryptophan hydroxylase gene 218A/C polymorphism is associated with somatic anxiety in major depressive disorder. Journal of Affective Disorders 65(1): 37-44, 2001

Monoamine oxidase: A gene polymorphism, tryptophan hydroxylase gene polymorphism and antidepressant response to fluvoxamine in Japanese patients with major depressive disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry 26(7-8): 1279-1283, 2002

Impact of the tryptophan hydroxylase 1 gene A218C polymorphism on amygdala activity in response to affective facial stimuli in patients with major depressive disorder. Genes Brain and Behavior 8(5): 512-518, 2009

Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): Frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studies. Genomics 81(1): 85-91, 2003

Alcohol use disorder and GABA B receptor gene polymorphisms in an Italian sample: haplotype frequencies, linkage disequilibrium and association studies. Annals of Human Biology 44(4): 384-388, 2017

Testing for candidate gene linkage disequilibrium using a dense array of single nucleotide polymorphisms in case-parents studies. Epidemiology 13(5): 545-551, 2002

Testing for Candidate Gene Linkage Disequilibrium Using a Dense Array of Single Nucleotide Polymorphisms in Case-Parents Studies. Epidemiology 13(5): 545-551, 2002

Dopamine beta-hydroxylase: two polymorphisms in linkage disequilibrium at the structural gene DBH associate with biochemical phenotypic variation. Human Genetics 102(5): 533-540, 1998

Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder. Molecular Psychiatry 10(12): 1126-1132, 2005

A case-control study of GRIN2B polymorphisms and major depressive disorder in the Chinese Han population. Psychiatry Research 262: 626-627, 2018