+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Cell cycle induction in post-mitotic neurons proceeds in concert with the initial phase of programmed cell death in rat



Cell cycle induction in post-mitotic neurons proceeds in concert with the initial phase of programmed cell death in rat



Neuroscience Letters 310(2-3): 173-177



Neuronal programmed cell death (PCD) is increasingly becoming recognized as a dynamic process that may be amenable to resolution. Critical to this resolution is the identification of the cellular pathways that modulate the initial stages of apoptotic death. In this regard, we examined whether the activation of a latent cell cycle was associated with the initial phase of PCD. We demonstrate that free radical nitric oxide induced PCD results in the rapid generation of membrane phosphatidylserine residue exposure. This early phase of PCD functions in parallel with an untoward attempt to enter the cell cycle in the same population of post-mitotic neurons. We therefore offer an attractive molecular target to prevent or reverse neuronal PCD by elucidating a novel mechanism through which the majority of neurons meet their demise by attempting to enter a latent cell cycle.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 010284544

Download citation: RISBibTeXText

PMID: 11585595

DOI: 10.1016/s0304-3940(01)02118-8


Related references

Programmed cell death of developing post-mitotic neurons in Apaf-1 mutant mice. Society for Neuroscience Abstracts 27(1): 66, 2001

Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of Cyclin D1 during programmed cell death. Neuron 12(2): 343-355, 1994

Nucleocytoplasmic Cdk5 is involved in neuronal cell cycle and death in post-mitotic neurons. Cell Cycle 10(8): 1208-1214, 2011

Generation of mononucleate cells from post-mitotic myotubes proceeds in the absence of cell cycle progression. Differentiation 66(4-5): 239-246, 2000

Early and late phases of apoptotic injury parallel attempted cell cycle induction in post mitotic neurons. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 198 10, 2002

Attempted Cell Cycle Induction in Post-Mitotic Neurons Occurs in Early and Late Apoptotic Programs Through Rb, E2F1, and Caspase 3. Current Neurovascular Research 3(1): 25-39, 2006

Attempted cell cycle induction in post-mitotic neurons occurs in early and late apoptotic programs through Rb, E2F1, and caspase 3. Current Neurovascular Research 3(1): 25-39, 2006

Sequestration of mitotic (M-phase) chromosomes in autophagosomes: mitotic programmed cell death in human Chang liver cells induced by an OH* burst from vanadyl(4). Anatomical Record 245(1): 1-8, 1996

Programmed cell death 2 protein induces gastric cancer cell growth arrest at the early S phase of the cell cycle and apoptosis in a p53-dependent manner. Oncology Reports 33(1): 103-110, 2015

The Cell Cycle and Cell Population Kinetics in the Programmed Cell Death in the Limb-Buds of Normal and 5-Bromodeoxyuridine- Treated Chick Embryos : (cell death/BrdU/cell cycle/limb-bud). Development, Growth & Differentiation 30(3): 261-270, 1988

Expression of cell cycle genes in postmitotic neurons during programmed cell death. Society for Neuroscience Abstracts 18(1-2): 43, 1992

Cell cycle kinetics and the induction of programmed cell death apoptosis. FASEB Journal 5(4): A519, 1991

Cell cycle kinetics and the induction of programmed cell death by cytotoxic agents in tumour cells. European Journal of Cancer 27(Suppl. 3): S41, 1991

Peptide growth factors actively prevent induction of the cell cycle during programmed cell death. Society for Neuroscience Abstracts 25(1-2): 299, 1999

The transcription factor E2F directs attempted cell cycle induction during neuronal programmed cell death. Society for Neuroscience Abstracts 25(1-2): 793, 1999