+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Central corneal thickness measurements in patients with normal tension glaucoma, primary open angle glaucoma, pseudoexfoliation glaucoma, or ocular hypertension



Central corneal thickness measurements in patients with normal tension glaucoma, primary open angle glaucoma, pseudoexfoliation glaucoma, or ocular hypertension



British Journal of Ophthalmology 85(7): 792-795



Background/aims: Recent studies have revealed patients with ocular hypertension to have thicker than normal central corneas and those with normal tension glaucoma to have thinner than normal ones, as determined by ultrasonic pachymetry. Since corneal thickness measurements and applanation tonometric estimates of intraocular pressure (IOP) correlate positively, monitoring of the former parameter have served as the basis for adjusting readings pertaining to the latter, with the consequence that many patients have had to be reclassified. With a view to validating these pachymetric studies, the central corneal thickness was determined in patients with normal tension glaucoma, primary open angle glaucoma, pseudoexfoliation glaucoma, or ocular hypertension, as well as that of normal subjects, using optical low coherence reflectometry, which is a new and more precise method than ultrasonic pachymetry. Methods: 34 patients with normal tension glaucoma, 20 with primary open angle glaucoma, 13 with pseudoexfoliation glaucoma, and 12 with ocular hypertension, together with 21 control subjects, were included in this observational, concurrent case-control study. One eye per individual was randomly selected for investigation. IOP was measured by Goldmann applanation tonometry and central corneal thickness by optical low coherence reflectometry. Results: Central corneal thickness was significantly higher (pltoreq0.001) in patients with ocular hypertension than in normal individuals or in subjects with either normal tension glaucoma, primary open angle glaucoma, or pseudoexfoliation glaucoma, there being no significant differences between the latter four groups. Patients with ocular hypertension were also significantly younger (pltoreq0.003) than those within any of the three glaucomatous groups. Conclusion: This study confirms that a significant number of patients with ocular hypertension have normal IOPs after the appropriate adjustments have been made for deviations from normal in their central corneal thickness. The accurate measurement of this latter parameter is important not only for individual patient care, in permitting more precise estimations of IOP, but also for clinical studies, in assuring a more reliable classification of subjects.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 010288298

Download citation: RISBibTeXText

PMID: 11423450

DOI: 10.1136/bjo.85.7.792


Related references

Comparative results of central corneal thickness measurements in primary open-angle glaucoma, pseudoexfoliation glaucoma, and ocular hypertension. Ophthalmic Surgery, Lasers and Imaging 39(1): 17-21, 2008

Evaluation of central corneal thickness in patients affected by ocular hypertension, primary open-angle glaucoma, normal tension glaucoma. Acta Ophthalmologica Scandinavica. Supplement 236: 49, 2002

The central corneal thickness in normal tension glaucoma, primary open angle glaucoma and ocular hypertension. Journal of Clinical and Diagnostic Research 7(6): 1063-1067, 2013

Corneal thickness measurements in normal tension glaucoma , primary open-angle glaucoma , and ocular hypertensive patients. IOVS 39(4): S935, March 15, 1998

Comparison of central and peripheral corneal thicknesses between normal subjects and patients with primary open angle glaucoma, normal tension glaucoma and pseudoexfoliation glaucoma. Klinische Monatsblatter für Augenheilkunde 224(8): 636-640, 2007

Corneal thickness in ocular hypertension, primary open-angle glaucoma, and normal tension glaucoma. Archives of Ophthalmology 117(1): 14-16, 1999

Central corneal thickness measurements in ocular hypertension, primary open angle glaucoma, glaucoma suspects and control subjects. Folia Medica 50(1): 35-39, 2008

Central corneal thickness in primary open angle glaucoma, pseudoexfoliative glaucoma, ocular hypertension, and normal population. European Journal of Ophthalmology 15(3): 324-328, 2005

A comparison of optic disc topographic parameters in patients with primary open angle glaucoma, normal tension glaucoma, and ocular hypertension. Graefe's Archive for Clinical and Experimental Ophthalmology 241(7): 541-545, 2003

Corneal hysteresis in normal subjects and in patients with primary open-angle glaucoma and pseudoexfoliation glaucoma. Ophthalmic Research 46(4): 187-191, 2015

Assessment of corneal biomechanical properties in normal tension glaucoma and comparison with open-angle glaucoma, ocular hypertension, and normal eyes. Journal of Glaucoma 21(7): 486-489, 2012

Evaluation of central corneal thickness in patients with ocular hypertension and primary open-angle glaucoma. Medicinski Glasnik 11(1): 115-119, 2015

Intracranial pressure in primary open angle glaucoma, normal tension glaucoma, and ocular hypertension: a case-control study. Investigative Ophthalmology and Visual Science 49(12): 5412-5418, 2008

Foveal thickness after phacoemulsification in patients with pseudoexfoliation syndrome, pseudoexfoliation glaucoma, or primary open-angle glaucoma. Yearbook of Ophthalmology 2009: 66-67, 2009

Foveal thickness after phacoemulsification in patients with pseudoexfoliation syndrome, pseudoexfoliation glaucoma, or primary open-angle glaucoma. Journal of Cataract and Refractive Surgery 34(11): 1953-1957, 2008