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Cerebrospinal fluid filtration in amyotrophic lateral sclerosis



Cerebrospinal fluid filtration in amyotrophic lateral sclerosis



European Journal of Neurology 6(5): 597-600



By means of a randomized, controlled and open study the authors wanted to find out if cerebrospinal (CSF)-filtration was of substantial benefit to patients with sporadic amyotrophic lateral sclerosis (SALS). Five SALS patients, aged 51-75 years, being treated with riluzole underwent CSF-filtration daily over five days (group A). Five other SALS patients, aged 52-70 years, were treated only with riluzole (group B). Although all five patients in the first group reported a subjective benefit following CSF-filtration, the Norris score, the Frenchay score, the vital capacity, the ulnar nerve F-wave persistence and the peak-ratio of the brachial biceps and anterior tibial muscles did not change significantly after five days of therapy, either in group A or in group B. In conclusion, filtration of 200-250 ml CSF daily, over five days, doe7s not seem to have a substantial therapeutic effect in patients with SALS.

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Accession: 010290586

Download citation: RISBibTeXText

PMID: 10457394

DOI: 10.1046/j.1468-1331.1999.650597.x


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