EurekaMag
+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

Changes in NADPH diaphorase expression in the fish visual system during optic nerve regeneration and retinal development


Changes in NADPH diaphorase expression in the fish visual system during optic nerve regeneration and retinal development



Neuroscience Research 40(4): 359-365



ISSN/ISBN: 0168-0102

PMID: 11463482

DOI: 10.1016/s0168-0102(01)00251-6

The various functions of nitric oxide (NO) in the nervous system are not fully understood, including its role in neuronal regeneration. The goldfish can regenerate its optic nerve after transection, making it a useful model for studying central nervous regeneration in response to injury. Therefore, we have studied the pattern of NO expression in the retina and optic tectum after optic nerve transection, using NADPH diaphorase histochemistry. NO synthesis was transiently up-regulated in the ganglion cell bodies, peaking during the period when retinal axons reach the tectum, between 20-45 days after optic nerve transection. Enzyme activity in the tectum was transiently down-regulated and then returned to control levels at 60 days after optic nerve transection, during synaptic refinement. To compare NO expression in the developing and regenerating retina, we have looked at NO expression in the developing zebrafish retina. In the developing zebrafish retina the pattern of staining roughly followed the pattern of development with the inner plexiform layer and horizontal cells having the strongest pattern of staining. These results suggest that NO may be involved in the survival of ganglion cells in the regenerating retina, and that it plays a different role in the developing retina. In the tectum, NO may be involved in synaptic refinement.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 010292449

Download citation: RISBibTeXText

Related references

Increased expression of NADPH-diaphorase in visual centres after unilateral optic nerve transection in the rat. Journal für Hirnforschung 36(4): 485-488, 1995

The development of NADPH-diaphorase and nitric oxide synthase in the visual system of the cichlid fish, Tilapia mariae. Brain Research Bulletin 54(5): 569-574, 2001

Distribution of the phosphorylated form of microtubule associated protein 1B in the fish visual system during optic nerve regeneration. Brain Research Bulletin 56(2): 131-137, 2001

Postnatal development of NADPH-diaphorase positive nerve cells in the visual cortex of the rat. Annals of Anatomy 177(6): 573-577, 1995

Postnatal development of NADPH-diaphorase/nitric oxide synthase positive nerve cells in the visual cortex of the rat. Journal für Hirnforschung 36(3): 313-328, 1995

Pax genes in development and maturation of the vertebrate visual system: implications for optic nerve regeneration. Histology and Histopathology 16(1): 239-249, 2001

Fish optic nerve oligodendrocytes support axonal regeneration of fish and mammalian retinal ganglion cells. Glia 8(1): 1-11, 1993

Optic target regulation of NADPH-diaphorase by larval retinal axons in Drosophila. Neuroscience Letters 262(1): 21-24, 1999

Development of NADPH-diaphorase activity in the central nervous system of the cichlid fish, Tilapia mariae. Brain Behavior and Evolution 54(3): 147-158, 1999

Stimulus dependencies in the time course of visual recovery during optic nerve regeneration in fish. IOVS Investigative Ophthalmology and Visual Science 32(4): 1271, 1991

Characterization of NADPH-diaphorase-positive glial cells of the tench optic nerve after axotomy. Archives Italiennes de Biologie 146(1): 35-52, 2008

Reciprocal changes in factor XIII and retinal transglutaminase expressions in the fish retina during optic nerve regeneration. Advances in Experimental Medicine and Biology 801: 759-764, 2014

Gene expression analysis of zebrafish retinal ganglion cells during optic nerve regeneration identifies KLF6a and KLF7a as important regulators of axon regeneration. Developmental Biology 312(2): 596-612, 2007

Developmental pattern of NADPH-diaphorase positive neurons in chick optic tectum is sensitive to changes in visual stimulation. Journal of Comparative Neurology 494(6): 1007-1030, 2006

Expression of SoxC Transcription Factors during Zebrafish Retinal and Optic Nerve Regeneration. Neuroscience Bulletin 33(1): 53-61, 2017