Section 11
Chapter 10,309

Characterization of the Streptomyces coelicolor A3 (2) wblE gene, encoding a homologue of the sporulation transcription factor

Homerová, D.; Sevcíková, J.; Kormanec, J.

Folia Microbiologica 48(4): 489-495


ISSN/ISBN: 0015-5632
PMID: 14533480
DOI: 10.1007/bf02931330
Accession: 010308165

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The gene corresponding to the recently identified whiB-paralogous gene wblE in S. coelicolor was found after sequencing the downstream region of the stress-response sporulation-specific sigma-factor gene, sigH, in S. coelicolor A3(2). Sequence analysis has revealed an ORF exhibiting high similarity to sporulation transcription factors WhiB and WhiD. A stable null mutant of the wblE gene was obtained by integrative transformation, via double cross-over.

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