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Co-occurrence of Parkinson's disease with progressive supranuclear palsy


Co-occurrence of Parkinson's disease with progressive supranuclear palsy



Acta Neuropathologica 103(5): 526-530



ISSN/ISBN: 0001-6322

PMID: 11935271

DOI: 10.1007/s00401-001-0483-7

Parkinson's disease (PD) and progressive supranuclear palsy (PSP) are distinct neurodegenerative disorders. We describe an 81-year-old woman with 3 years of progressive gait unsteadiness, frequent falls, and mild cognitive dysfunction, all considered clinically to be an early fronto-temporal neurodegenerative disorder. She died of an acute myocardial infarction. Examination of her brain revealed alpha-synuclein- and tau-positive inclusions diagnostic of PD and PSP. Immunoelectron microscopy and Western blot analysis confirmed combined PD/PSP. This case provides strategies for the reliable molecular validation of concomitant PD and PSP, and demonstrates the utility of these techniques in patients with atypical clinical presentations.

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Accession: 010339947

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