+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Co-occurrence of Parkinson's disease with progressive supranuclear palsy

Co-occurrence of Parkinson's disease with progressive supranuclear palsy

Acta Neuropathologica 103(5): 526-530

ISSN/ISBN: 0001-6322

PMID: 11935271

DOI: 10.1007/s00401-001-0483-7

Parkinson's disease (PD) and progressive supranuclear palsy (PSP) are distinct neurodegenerative disorders. We describe an 81-year-old woman with 3 years of progressive gait unsteadiness, frequent falls, and mild cognitive dysfunction, all considered clinically to be an early fronto-temporal neurodegenerative disorder. She died of an acute myocardial infarction. Examination of her brain revealed alpha-synuclein- and tau-positive inclusions diagnostic of PD and PSP. Immunoelectron microscopy and Western blot analysis confirmed combined PD/PSP. This case provides strategies for the reliable molecular validation of concomitant PD and PSP, and demonstrates the utility of these techniques in patients with atypical clinical presentations.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 010339947

Download citation: RISBibTeXText

Related references

A follow-up study on brainstem atrophy in progressive supranuclear palsy--when does brain MRI contribute to the differential diagnosis between progressive supranuclear palsy and Parkinson disease?. Rinsho Shinkeigaku 43(7): 392-397, 2003

Accuracy of the National Institute for Neurological Disorders and Stroke/Society for Progressive Supranuclear Palsy and neuroprotection and natural history in Parkinson plus syndromes criteria for the diagnosis of progressive supranuclear palsy. Movement disorders: official journal of the Movement Disorder Society 28(4): 504-509, 2013

Progressive supranuclear palsy: extensive neuropil threads in addition to neurofibrillary tangles. very similar antigenicity of subcortical neuronal pathology in progressive supranuclear palsy and Alzheimer's disease. Acta Neuropathologica 77(1): 61-68, 1988

Parkinson's disease and progressive supranuclear palsy. Archives of Internal Medicine 145(5): 952, 1985

MR imaging index for differentiation of progressive supranuclear palsy from Parkinson disease and the Parkinson variant of multiple system atrophy. Radiology 246(1): 214-221, 2008

Apparent diffusion coefficient measurements of the middle cerebellar peduncle differentiate the Parkinson variant of MSA from Parkinson's disease and progressive supranuclear palsy. Brain: a Journal of Neurology 129(Part 10): 2679-2687, 2006

Different MAPT haplotypes are associated with Parkinson's disease and progressive supranuclear palsy. Neurobiology of Aging 32(3): 547.E11-16, 2011

"Parkinson's disease" on the way to progressive supranuclear palsy: a review on PSP-parkinsonism. Neurological Sciences: Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 42(12): 4927-4936, 2021

Evaluation of Retinal Changes in Progressive Supranuclear Palsy and Parkinson Disease. Journal of Neuro-Ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society 38(2): 151-155, 2018

Striatal phosphoproteins in Parkinson disease and progressive supranuclear palsy. Proceedings of the National Academy of Sciences of the United States of America 86(7): 2493-2497, 1989

The subthalamic nucleus in Parkinson's disease and progressive supranuclear palsy. Journal of Neuropathology and Experimental Neurology 56(2): 132-142, 1997

Comparison of swallowing function in Parkinson's disease and progressive supranuclear palsy. Movement Disorders: Official Journal of the Movement Disorder Society 12(3): 322-327, 1997

Comparison of the vesicourethral function between progressive supranuclear palsy and Parkinson's disease. Hinyokika Kiyo. Acta Urologica Japonica 39(6): 523-528, 1993

PET imaging of the dopamine transporter in progressive supranuclear palsy and Parkinson's disease. Neurology 52(6): 1221-1226, 1999

Neuropsychiatric symptoms of patients with progressive supranuclear palsy and Parkinson's disease. Journal of Neuropsychiatry and Clinical Neurosciences 13(1): 42-49, 2001