+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Coincidence of Crohn's disease and a high-risk gastrointestinal stromal tumor of the terminal ileum



Coincidence of Crohn's disease and a high-risk gastrointestinal stromal tumor of the terminal ileum



Digestion 60(4): 363-366



A 51-year-old male patient presented with characteristic radiologic features of Crohn's disease in the terminal ileum plus a large tumorous lesion in the right lower abdomen. Because of rapid crescent symptoms of bowel obstruction, the patient underwent surgery revealing a high-risk gastrointestinal stromal tumor (GIST) of the terminal ileum within an area of Crohn's ileitis. Whereas the association of chronic inflammatory bowel disease (IBD) and gastrointestinal adenocarcinorna is well known, other primary intestinal tumors are rare in these patients, particularly at the time of onset of clinical symptoms. This is the 3rd patient reported in the literature with a sarcoma complicating IBD, and in fact, the first description of the coincidence of Crohn's disease and GIST. Though the present case is likely to be a mere coincidence of two pathologically distinct entities (without any potential causal relationship), it should remind one of the possibility of small bowel 'Crohn's carcinoma'in patients with a sudden change in symptomatology as well as in those in whom intestinal obstruction fails to resolve with adequate therapy.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 010342837

Download citation: RISBibTeXText

PMID: 10394032


Related references

Coincidence of Crohn’s Disease and a High-Risk Gastrointestinal Stromal Tumor of the Terminal Ileum. Digestion 60(4): 363-366, 1999

Crohn's disease and a gastrointestinal stromal tumor in an 81-year-old man--a rare coincidence. Zentralblatt für Chirurgie 130(6): 597-599, 2005

Coincidence of active Crohn's disease and florid endometriosis in the terminal ileum: a case report. World Journal of Gastroenterology 19(27): 4413-4417, 2013

Massive lower gastrointestinal bleeding from terminal ileum in Crohn's disease. La Tunisie Medicale 87(4): 306, 2009

Gastrointestinal: Crohn's disease in the terminal ileum with an ileo-ileal fistula: Radiologic-pathologic correlation. Journal of Gastroenterology and Hepatology 32(6): 1133, 2017

Tumor necrosis and >20 mitoses per 50 high-power fields can distinguish 'very high-risk' and 'highest-risk' within 'high-risk' gastric gastrointestinal stromal tumor. Future Oncology 14(7): 621-629, 2018

Synchronous adenocarcinoma and carcinoid tumor of the terminal ileum in a Crohn's disease patient. Bmc Cancer 5: 157, 2005

Is the length of postoperative recurrence on the neo ileum terminal ileum predictable in Crohn's disease?. Journal of Crohn's and Colitis 5(1): 24-27, 2011

Twenty-six-year-old female with assumed Crohn's disease and a gastrointestinal stromal tumor: Response. Inflammatory Bowel Diseases 15(4): 489-490, 2009

Gastrointestinal stromal tumor causing small bowel intussusception in a patient with Crohn's disease. World Journal of Gastroenterology 15(41): 5224-5227, 2009

GLP-2 receptors in human disease: high expression in gastrointestinal stromal tumors and Crohn's disease. Molecular and Cellular Endocrinology 364(1-2): 46-53, 2012

Gastrointestinal stromal tumor of the ileum in MRI. Rofo 176(2): 261-262, 2004

Hypervascular gastrointestinal stromal tumor of the ileum. Rofo 176(12): 1843-1844, 2004

Coincidence of Crohns disease and leiomyosarcoma of the terminal ileum Case report. Annals of Hematology 65(Suppl. ): A14, 1992

Crohn's disease and stromal sarcoma of the small bowel--a rare coincidence. Zeitschrift für Gastroenterologie 40(3): 193-196, 2002