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Comparison of the sperm quality necessary for successful intrauterine insemination with World Health Organization threshold values for normal sperm



Comparison of the sperm quality necessary for successful intrauterine insemination with World Health Organization threshold values for normal sperm



Fertility & Sterility 71(4): 684-689



Objective: To compare World Health Organization threshold values for normal sperm with the initial sperm quality necessary for successful IUI. Design: Retrospective study. Setting: Private fertility clinic. Patient(s): One thousand eight hundred forty-one couples undergoing 4,056 cycles of IUI. Intervention(s): Intrauterine insemination. Main Outcome Measure(s): Relation of initial sperm quality to fecundity. Result(s): Progressive motility and total motile sperm count were the initial sperm characteristics most closely related to pregnancy on discriminant analysis. The per-cycle pregnancy rate averaged 11.1% during the first three IUI cycles. Pregnancy rates were gtoreq8.2% per cycle when the initial sperm values were a concentration of gtoreq5 X 106/mL, a total count of gtoreq10 X 106, progressive motility of gtoreq30%, or a total motile sperm count of gtoreq5 X 106. Minimal increases in fecundity occurred when initial values were greater than these threshold levels. The lowest initial values that resulted in pregnancy were a concentration of 2 X 106/mL, a total count of 5 X 106, motility of 17%, and a total motile sperm count of 1.6 X 106. Pregnancy rates were <3.6% when initial values were between the threshold levels and the lowest levels. Conclusion(s): The sperm quality that is necessary for successful IUI is lower than World Health Organization threshold values for normal sperm. Intrauterine insemination is effective therapy for male factor infertility when initial sperm motility is gtoreq30% and the total motile sperm count is gtoreq5 X 106. When initial values are lower. IUI has little chance of success.

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Accession: 010363337

Download citation: RISBibTeXText

PMID: 10202879

DOI: 10.1016/s0015-0282(98)00519-6


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