+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Copper, ceruloplasmin, superoxide dismutase and iron parameters in Parkinson's disease



Copper, ceruloplasmin, superoxide dismutase and iron parameters in Parkinson's disease



Pharmacology and Toxicology 85(5): 239-243



In a previous study we found copper dyshomeostasis in patients with Alzheimer's disease. In this study, levels of copper in plasma, of ceruloplasmin in serum and ceruloplasmin oxidative activity as well as superoxide dismutase (SOD) activity in erythrocytes were determined in 40 patients with Parkinson's disease and their healthy age- and gender-matched controls. Copper concentrations did not differ significantly in the two groups, whereas both ceruloplasmin concentrations and ceruloplasmin oxidative activity were significantly lower in the patients, also relative to ceruloplasmin mass. SOD activity was not significantly different in the two groups but decreased significantly with the duration of disease. The same was found for ceruloplasmin oxidative activity. Ceruloplasmin oxidative activity and SOD activity did not decrease with age. Levels of serum iron, serum ferritin and total iron binding capacity were determined in about 30 of the patients and an equal number of controls and were not found to differ. Transferrin levels were significantly lower in the patients than in their controls but, conversely, the transferrin saturation was significantly higher in the patients. The results indicate that patients with Alzheimer's disease and Parkinson's disease have defective ceruloplasmin and SOD activities in common and that these defects are not necessarily associated with major disturbances in iron homeostasis.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 010387758

Download citation: RISBibTeXText

PMID: 10608487

DOI: 10.1111/j.1600-0773.1999.tb02015.x


Related references

Anemia of inflammatory disease in the dog: ferrokinetics of adjuvant-induced anemia. American Journal of Veterinary Research 42(4): 583-585, 1981

Ceruloplasmin and acute phase protein levels are associated with cardiovascular disease in chronic dialysis patients. Journal of Nephrology 17(5): 715-720, 2004

Effect of Presentation Rate on Word List Learning in Patients with Dementia of the Alzheimer Type. Dementia and Geriatric Cognitive Disorders 9(4): 214-218, 1998

Studies on the reactivity of fused thiazole toward nucleophilic reagents: Synthesis of new thiazolo-derivatives of potential antischistosomal activity. Heteroatom Chemistry 16(2): 121-131, 2005

The effect of feeding mice during gestation and nursing with Rhodiola kirilowii extracts or epigallocatechin on CD4 and CD8 cells number and distribution in the spleen of their progeny. Central-European Journal of Immunology 42(1): 10-16, 2017

Copper, ceruloplasmin and superoxide dismutase (SOD1) in patients with Down's syndrome. Pharmacology and Toxicology 89(6): 320-325, 2002

Regulation of antral gastrin content. American Journal of Physiology 245(6): G725-G729, 1983

Identification of iron reductase isozymes in soybeans. Journal of Plant Nutrition 19(2): 457-467, 1996

Prokaryotic introns and inteins: A panoply of form and function. Journal of Bacteriology 177(14): 3897-3903, 1995

The Palearctic Oystercatcher Haematopus ostralegus, a Natural Definitive Host for Gymnophalloides seoi. The Journal of Parasitology 86(2): 418-419, 2000

Purification and characterization of invertase from Lactobacillus reuteri CRL 1100. Current Microbiology 40(3): 181-184, 2000

Copper zinc superoxide dismutase manganese superoxide dismutase and malondialdehyde in atopic dermatitis and normal human skin. 1985

Superoxide dismutase activity and the effect of N-methyl-D-aspartate antagonists on lipid peroxidation in the early phase of cold injury. Research in Experimental Medicine. Zeitschrift für die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie 198(6): 341-347, 1999

Activities of some serum enzymes in halothane reacted and non-reacted pigs. Acta Veterinaria Hungarica 37(1-2): 117-121, 1989

Effects of copper on the tyrosinase of liver pigment cells from Rana esculenta L. Comparative Biochemistry and Physiology. B, Comparative Biochemistry 96(2): 393-397, 1990