Correlation between serum creatinine, creatinine clearance, the calculated creatinine clearance and the glomerular filtration rate in heart transplant patients

Cantarovich, M.; Giannetti, N.; Cecere, R.

Journal of Heart and Lung Transplantation the Official Publication of the International Society for Heart Transplantation 21(7): 815-817


ISSN/ISBN: 1053-2498
PMID: 12100909
DOI: 10.1016/s1053-2498(01)00419-3
Accession: 010390396

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Assessment of glomerular filtration rate (GFR) in heart transplant (HTx) patients is based on serum creatinine (sCr), the endogenous creatinine clearance (CCr) and radionuclide GFR (rGFR); however, the latter is expensive and time consuming. We reviewed the data of 32 adult HTx patients to determine the correlation, between sCr, CCr, the calculated CCr (Calc.CCr; based on gender, age, weight and sCr) and rGFR in long-term (>1 year). HTx patients receiving calcineurin inhibitors. The Calc.CCr was found to have the best correlation with rGFR (r2=0.65), followed by CCr (r2=0.53) and sCr (r2=0.38). The use of Calc.CCr to estimate GFR may be cost-effective in assessing renal function after HTx.