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Correlation between the administered dose of DHEA and serum levels of DHEA and DHEA-S in human volunteers: Analysis of published data



Correlation between the administered dose of DHEA and serum levels of DHEA and DHEA-S in human volunteers: Analysis of published data



Clinical Biochemistry 32(5): 355-361, July



Objectives: Studies from both experimental animals and humans suggest that administration of exogenous DHEA may have beneficial endocrine-metabolic, immunologic and neurologic effects. Several groups have administered DHEA to humans, but to the best of our knowledge, no one at this point has published a summary of the relationship between the administered dose of DHEA and the serum levels of steroids attained. Design: We summarize the relationship between the administered dose of DHEA and the resulting serum level of DHEA and DHEA-S, in humans, from 18 published articles. Results: Serum levels of DHEA and DHEA-S increase with increasing doses. Doses above 50 mg/day result in levels that are at or above the upper limit of normal for healthy young adults. At doses above 300 mg/day the increment of serum DHEA and DHEA-S appears to reach a plateau. Conclusions: Those wanting to use supplemental DHEA might consider that doses of 300 mg/day are maximal; they clearly result in supraphysiologic concentrations and above this level doses may have increased side effects without significantly increasing the effective level of serum hormone.

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Accession: 010390460

Download citation: RISBibTeXText

PMID: 10480450

DOI: 10.1016/s0009-9120(99)00021-1



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