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Deoxyribozyme-based logic gates

Stojanovic, M.N.; Mitchell, T.Elizabeth.; Stefanovic, D.

Journal of the American Chemical Society 124(14): 3555-3561

2002

ISSN/ISBN: 0002-7863
PMID: 11929243
DOI: 10.1021/ja016756v
Accession: 010427107
We report herein a set of deoxyribozyme-based logic gates capable of generating any Boolean function. We construct basic NOT and AND gates, followed by the more complex XOR gate. These gates were constructed through a modular design that combines molecular beacon stem-loops with hammerhead-type deoxyribozymes. Importantly, as the gates have oligonucleotides as both inputs and output, they open the possibility of communication between various computation elements in solution. The operation of these gates is conveniently connected to a fluorescent readout.

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