+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

Dietary iron and the integrity of the developing rat brain: a study with the artificially-reared rat pup



Dietary iron and the integrity of the developing rat brain: a study with the artificially-reared rat pup



Cellular and Molecular Biology 46(3): 501-515



Inadequate iron nutrition is thought to affect many aspects of brain development. Iron is a component of enzyme systems in DNA synthesis, the respiratory chain, neurotransmitter and lipid metabolism. The iron content of the striatum increases post-natally, with neuronal differentiation, myelin lipid and receptor formation: Seventy percent of the iron in the brain is associated with myelin. In an attempt to dissociate the global effects of under-and/or malnutrition and to produce exclusively an iron deficiency, we have used the gastrostomy-reared rat pup fed milk substitutes which vary only in their iron content. To ensure the pups did not have adequate iron reserves at birth, dams were fed a meal diet of low iron content (3 ppm) throughout gestation. The pups were then artificially reared on milk with (43 ppm), and without added iron (2.5 ppm) from 6 up to 21 days after birth. At 21 days of age, body weights of iron deficient pups were about 90% those of control animals. At 21 days of age, the pups were weaned, then fed standard laboratory rat chow. Brain was examined at 42 days of age (for young adults) and up to 6 months of age (180 days as mature adults). Morphometric analysis of sagittal sections of the cerebellum at 21 and 63 days of age revealed a deficit in white matter formation in pups fed low-iron at 21 days of age when compared to controls. This deficit was partially recouped by age 63 days. By contrast, animals fed milk supplemented with iron showed greater definition in white matter formation than controls at 21 days of age; indicative of precocious maturation of the white matter tracts. Our findings indicate that iron deficiency, without under/mal-nutrition and other variables, does not result in extensive growth deficits in body and brain weight. However, the iron status profoundly influences the development of myelination in that the process is delayed in iron deficiency.

(PDF emailed within 1 workday: $29.90)

Accession: 010459954

Download citation: RISBibTeXText

PMID: 10872738



Related references

Dietary iron status and the integrity of the developing brain. International Journal of Developmental Neuroscience 14(SUPPL 1): 103, 1996

Variations in dietary iron alter the binding of iron regulatory proteins to iron response element in the brain of developing rats. FASEB Journal 14(4): A751, March 15, 2000

Comparison of Brain Development in Sow-Reared and Artificially Reared Piglets. Frontiers in Pediatrics 4(): 95-95, 2016

Variations in dietary iron alter brain iron metabolism in developing rats. Journal of Nutrition 130(2): 254-263, 2000

Iron and the integrity of lipid myelin specific mrna levels in developing brain. FASEB Journal 6(4): A1501, 1992

Hypothalamus integrity and appetite regulation in low birth weight rats reared artificially on a high-protein milk formula. Journal of Nutritional Biochemistry 22(10): 956-963, 2012

Supplemental iron for the artificially reared piglet. Journal of Animal Science 40(4): 621-623, 1975

Effect of changes in dietary fat on body composition of artificially reared rats. Nutrition Reports International 34(4): 681-690, 1986

Dietary ascorbic acid for neonatal pigs reared artificially. International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift für Vitamin- und Ernahrungsforschung. Journal International de Vitaminologie et de Nutrition 55(4): 413-419, 1985

Effect of iron supplementation on artificially-reared lambs weaned at 14 days of age. SID Research Journal, Sheep Industry Development 5(1): 1-6, 1988

Effect of type of dietary lipid on growth and body composition of artificially reared rats. Federation Proceedings 45(3): 364, 1986

Neonatal dietary zinc deficiency in artificially reared rat pups retards behavioral development and interacts with essential fatty acid deficiency to alter liver and brain fatty acid composition. Journal of Nutrition 129(10): 1773-1781, 1999

Effect of parenteral administration of iron dextran on the development of the haemogram in artificially reared lambs. Berliner und Munchener Tierarztliche Wochenschrift 92(12): 236-240, 1979

Endogenous corticosterone rather than dietary sucrose as a modulator for intestinal sucrase activity in artificially reared rat pups. Journal of Nutrition 116(7): 1334-1342, 1986

Influence of a high dietary concentration of Furoxone (furazolidone) on the gastrointestinal flora of artificially reared piglets.. Vlaams Diergeneeskundig Tijdschrift 41(1): 7-21, 1972