EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Dietary taurine manipulations in aged male Fischer 344 rat tissue: taurine concentration, taurine biosynthesis, and oxidative markers



Dietary taurine manipulations in aged male Fischer 344 rat tissue: taurine concentration, taurine biosynthesis, and oxidative markers



Biochemical Pharmacology 62(1): 29-39



Taurine (TAU) is a ubiquitous sulfur-containing amino acid that has been proposed to be an antioxidant. The concentration of TAU decreases during aging, which may increase susceptibility to oxidative stress. Our study attempted to elucidate the mechanism for the age-dependent decrease in TAU content by examining TAU biosynthesis in aged rats. We also examined the effects of dietary TAU manipulations on TAU content and oxidative markers in aged male Fischer 344 (F344) rats. Adult (9 months) and aged (26 months) rats fed control diets, aged rats fed control diet and TAU-supplemented (1.5%) water, and aged rats fed a TAU-deficient diet were used. We observed a significant age-related decrease in TAU content in liver, kidney, and cerebellum. Dietary TAU supplementation increased tissue TAU content, whereas dietary TAU restriction had no effect. Enzyme-dependent TAU synthesis showed an age-dependent reduction in liver that was decreased further by TAU supplementation. Protein carbonyl content was elevated in the cerebral cortex and kidney of aged rats and was attenuated by TAU supplementation. A trend for a decrease in protein and acid-soluble thiol contents in hepatic tissue of aged rats was observed, and this was attenuated with dietary TAU supplementation. Our data show that a decrease in hepatic TAU biosynthesis may cause, in part, the observed decline in tissue TAU content in aged F344 rats, and TAU supplementation can restore TAU levels. Our study indicates that a decline in TAU content may exacerbate oxidative stress in aged rats, which can be reversed by dietary TAU supplementation.

(PDF emailed within 0-6 h: $19.90)

Accession: 010460506

Download citation: RISBibTeXText

PMID: 11377394

DOI: 10.1016/s0006-2952(01)00647-5



Related references

Hepatic taurine concentration and dietary taurine as regulators of bile acid conjugation with taurine. Gastroenterology 75(1): 71-75, 1978

Tissue taurine content, activity of taurine synthesis enzymes and conjugated bile acid composition of taurine-deprived and taurine-supplemented rhesus monkey infants at 6 and 12 mo of age. Journal of Nutrition 121(6): 854-862, 1991

Effects of dietary taurine supplementation or deprivation in aged male Fischer 344 rats. Mechanisms of Ageing & Development 107(1): 73-91, Feb 1, 1999

Effect of dietary taurine on influx and biosynthesis of taurine in the heart. Pharmacologist: 159, 1976

Effect of dietary intake of taurine and protein on taurine concentration in plasma of the cat. Federation Proceedings 39(3): ABSTRACT 4102, 1980

The effect of dietary taurine content on the plasma taurine concentration of the cat. British Journal of Nutrition 66(2): 227-235, 1991

Influence of testosterone on the concentration of hypo taurine and taurine in the reproductive tract of the male guinea pig rat and mouse. Huxtable, Ryan And Andre Barbeau (Ed ) Taurine Proceedings Of An International Symposium Tucson, Ariz , U S A , March 1975 Xiv+398p Illus Raven Press: New York, N Y , U S A Isbn 0-89004-064-8 327-334, 1976

Metal complexes of taurine The first reported solution equilibrium studies for complex formation by taurine at physiological pH; the copper -glycylglycinate-taurine and the copper -glycylaspartate-taurine systems. Journal of Inorganic Biochemistry 77(3-4): 135-139, 1999

Metal complexes of taurine. The first reported solution equilibrium studies for complex formation by taurine at physiological pH; the copper(II)-glycylglycinate-taurine and the copper(II)-glycylaspartate-taurine systems. Journal of Inorganic Biochemistry 77(3-4): 135-139, 1999

Metal complexes of taurine. The first reported solution equilibrium studies for complex formation by taurine at physiological pH; the copper(II)-glycylglycinate-taurine and the copper(II)-glycylaspartate-taurine systems. Journal of Inorganic Biochemistry 77(3-4): 135-139, 2000

The effect of dietary supplementation with cysteic acid on the plasma taurine concentration of cats maintained on a taurine-restricted diet. Advances in Experimental Medicine and Biology 315: 23-32, 1992

Taurine as a ligand. An investigation of Ag(I)- and Cd(II)-taurine complex equilibria by direct and competitive techniques, and use of the Ag(I)-taurine complex electrode to assess taurine in solution. Talanta 46(1): 91-99, 1998

Taurine as a ligand An investigation of Ag - and Cd -taurine complex equilibria by direct and competitive techniques, and use of the Ag -taurine complex electrode to assess taurine in solution. Talanta 46(1): 91-99, 1998

Taurine as a ligand. An investigation of Ag(I)- and Cd(II)-taurine complex equilibria by direct and competitive techniques, and use of the Ag(I)-taurine complex electrode to assess taurine in solution. Talanta 46(1): 91-99, 2008

Effects of dietary taurine on whole body and tissue taurine levels of guppy and eel. Bulletin of the Japanese Society of Scientific Fisheries 54(9): 1647-1652, 1988